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Article
Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
In EGFR-mutant and MET-amplified lung cancer resistant to EGFR inhibitors, double blockade of EGFR and MET is considered as a reasonable strategy despite increasing toxicity. This study evaluated the single MET i...
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Article
Open AccessPatient-derived cell-based pharmacogenomic assessment to unveil underlying resistance mechanisms and novel therapeutics for advanced lung cancer
A pharmacogenomic platform using patient-derived cells (PDCs) was established to identify the underlying resistance mechanisms and tailored treatment for patients with advanced or refractory lung cancer.
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Article
Open AccessStem cell behaviors on periodic arrays of nanopillars analyzed by high-resolution scanning electron microscope images
The biocompatible polyurethane acrylate (PUA) nanopillars were fabricated by soft lithography using three different sizes of nanobeads (350, 500, and 1000 nm), and the human adipose-derived stem cells (hASCs) ...
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Article
Open AccessSurvival factor SvfA plays multiple roles in differentiation and is essential for completion of sexual development in Aspergillus nidulans
The first member of the velvet family of proteins, VeA, regulates sexual development and secondary metabolism in the filamentous fungus Aspergillus nidulans. In our study, through comparative proteome analysis us...
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Article
The effect of combination therapy on critical-size bone defects using non-activated platelet-rich plasma and adipose-derived stem cells
Non-activated platelet-rich plasma (nPRP) slowly releases growth factors that induce bone regeneration. Adipose tissue-derived stem cells (ASCs) are also known to induce osteoblast differentiation. In this stu...
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Article
In vitro antibacterial and early stage biofilm inhibitory potential of an edible chitosan and its phenolic conjugates against Pseudomonas aeruginosa and Listeria monocytogenes
In the present study, the antibacterial potential of chitosan grafted with phenolics (CPCs) such as caffeic acid (CCA), ferulic (CFA), and sinapic acid (CSA) were evaluated against foodborne pathogens like Pseudo...
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Article
Open AccessAdipose Tissue Formation Utilizing Fat Flap Distraction Technique
Co-regulation between adipocytes and supporting vasculature is considered an important process in adipose tissue generation. The objective of this study was to evaluate the mechanical and biological effects of...
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Article
Acceleration of osteogenesis by platelet-rich plasma with acellular dermal matrix in a calvarial defect model
The effects of platelet-rich plasma (PRP) on improvement of bone regeneration have been widely investigated. However, use of a proper scaffold is also important to the delivery of bioactive materials. The aim ...
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Article
Transcriptional regulation of fksA, a β-1,3-glucan synthase gene, by the APSES protein StuA during Aspergillus nidulans development
The temporal and spatial regulation of β-1,3-glucan synthesis plays an important role in morphogenesis during fungal growth and development. Northern blot analysis showed that the transcription of fksA, the gene ...
