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Article
Open AccessImmune disturbance leads to pulmonary embolism in COVID-19 more than classical risk factors: a clinical and histological study
COVID-19 induces endotheliitis and one of the main complications is enhanced coagulation. The incidence of pulmonary embolism (PE) in COVID-19 (CPE) has increased and clinical features for a rigorous analysis ...
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Article
Open AccessEosinophil-mast cell pattern of intraepithelial infiltration as a marker of severity in CRSwNP
Chronic rhinosinusitis with nasal polyps (CRSwNP) is defined as a Type 2 eosinophilic disease, while CRSsNP is considered a Type 1 neutrophilic disease. Since neutrophils are also activated in eosinophilic CRS...
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Article
Open AccessIntracranial mesenchymal tumor with (novel) COX14::PTEN rearrangement
Mesenchymal tumors of the central nervous system (CNS) include numerous entities, with different pathological features and biological behavior. Mesenchymal non-meningothelial tumors are rare and comprise neopl...
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Article
Open AccessMixed-dust pneumoconiosis in a dental technician: a multidisciplinary diagnosis case report
In dental laboratories, exposure to crystalline silica can occur during procedures that generate suspended mineral dusts, e.g. dispersion of mixing powders, removal of castings from molds grinding, polishing o...
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Article
A convolutional neural network with transfer learning for automatic discrimination between low and high-grade synovitis: a pilot study
Ultrasound-guided synovial tissue biopsy (USSB) may allow personalizing the treatment for patients with inflammatory arthritis. To this end, the quantification of tissue inflammation in synovial specimens can ...
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Article
Early tongue carcinomas (clinical stage I and II): echo-guided three-dimensional diode laser mini-invasive surgery with evaluation of histological prognostic parameters. A study of 85 cases with prolonged follow-up
The management of patients with early stage (cT1–T2) tongue squamous cell carcinoma without clinicoradiologic evidence of neck node metastasis (cN0) has been widely debated over the last 3 decades and still re...
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Article
RNAscope dual ISH–IHC technology to study angiogenesis in diffuse large B-cell lymphomas
Diffuse large B-cell lymphomas (DLBCLs) are the most common types of Non-Hodgkin’s lymphomas and are highly heterogeneous in terms of phenotype and treatment response. The natural course of DLBCLs tumor progre...
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Reference Work Entry In depth
Adenomyoepithelioma
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Reference Work Entry In depth
Microglandular Adenosis
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Article
Vascular density and inflammatory infiltrate in primary oral squamous cell carcinoma and after allogeneic hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) recipients have been reported to have an increased risk of chronic graft versus host disease (cGVHD) and hematological and solid cancers. Oral manifestations are ...
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Living Reference Work Entry In depth
Microglandular Adenosis
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Article
Computer-driven quantitative image analysis in the assessment of tumor cell and T cell features in diffuse large B cell lymphomas
Diffuse large B cell lymphoma (DLBCL) is recognized as the most common non-Hodgkin lymphoma subtype. Advanced high-resolution digital scans of pathology slides have enabled the development of computer-based im...
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Living Reference Work Entry In depth
Adenomyoepithelioma
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Article
Open AccesspIL6-TRAIL-engineered umbilical cord mesenchymal/stromal stem cells are highly cytotoxic for myeloma cells both in vitro and in vivo
Mesenchymal/stromal stem cells (MSCs) are favorably regarded in anti-cancer cytotherapies for their spontaneous chemotaxis toward inflammatory and tumor environments associated with an intrinsic cytotoxicity a...
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Article
Open AccessLangerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report
Langerhans cell histiocytosis is a sporadic disease caused by an uncontrolled pathogenic clonal proliferation of dendritic cells that have Langerhans cell characteristics. New treatment protocols provided by t...
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Article
T cells, mast cells and microvascular density in diffuse large B cell lymphoma
Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammator...
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Article
Interval sentinel lymph nodes in melanoma: a digital pathology analysis of Ki67 expression and microvascular density
The presence of interval sentinel lymph nodes in melanoma is documented in several studies, but controversies still exist about the management of these lymph nodes. In this study, an immunohistochemical evalu...
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Article
Open AccessEverolimus restrains the paracrine pro-osteoclast activity of breast cancer cells
Breast cancer (BC) cells secrete soluble factors that accelerate osteoclast (OC) differentiation, leading to the formation of osteolytic bone metastases. In the BOLERO-2 trial, BC patients with bone involvemen...
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Article
Open AccessClusterin transcript variants expression in thyroid tumor: a potential marker of malignancy?
Clusterin (CLU) is a ubiquitous multifunctional factor involved in neoplastic transformation. The CLU transcript variants and protein forms play a crucial role in balancing cells proliferation and death.
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Article
Invasive lobular breast cancer: subtypes and outcome
Invasive lobular carcinoma (ILC) is the most common “special type” of breast cancer. Although conflicting literature data are available on the outcome of ILC, recently reported data indicate that ILC carries a...
