6 Result(s)
within
Etienne Waelkens
Life Sciences
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Article
Open AccessCytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells
The 78-kDa glucose-regulated protein (GRP78) is an ubiquitously expressed endoplasmic reticulum chaperone, with a central role in maintaining protein homeostasis. Recently, an alternative role for GRP78 under ...
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Article
Identification of PP2A/Set Binding Sites and Design of Interacting Peptides with Potential Clinical Applications
Protein phosphatase 2A (PP2A) is known to be a negative regulator of several survival and proliferating pathways that are frequently altered in cancer. In addition to chemical enzymatic inhibitors of the PP2A ...
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Article
Open AccessTissue specific analysis reveals a differential organization and regulation of both ethylene biosynthesis and E8 during climacteric ripening of tomato
Solanum lycopersicum or tomato is extensively studied with respect to the ethylene metabolism during climacteric ripening, focusing almost exclusively on fruit pericarp. In this work the ethylene biosynthesis pat...
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Article
Open AccessProteomic biomarkers predicting lymph node involvement in serum of cervical cancer patients. Limitations of SELDI-TOF MS
Lymph node status is not part of the staging system for cervical cancer, but provides important information for prognosis and treatment. We investigated whether lymph node status can be predicted with proteomi...
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Article
Venom components from Citharischius crawshayi spider (Family Theraphosidae): exploring transcriptome, venomics, and function
Despite strong efforts, knowledge about the composition of the venom of many spider species remains very limited. This work is the first report of transcriptome and venom analysis of the African spider Citharisch...
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Chapter and Conference Paper
Semi-supervised Learning of Sparse Linear Models in Mass Spectral Imaging
We present an approach to learn predictive models and perform variable selection by incorporating structural information from Mass Spectral Imaging (MSI) data. We explore the use of a smooth quadratic penalty ...
