-
Article
Open AccessThe Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer
Human papillomaviruses (HPVs) cause most cervical cancers and an increasing number of anogenital and oral carcinomas, with most cases caused by HPV16 or HPV18. HPV hijacks host signalling pathways to promote c...
-
Article
Open AccessE7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer
Human papillomaviruses (HPV) are a major cause of malignancy, contributing to ~5% of all human cancers worldwide, including most cervical cancer cases and a growing number of anogenital and oral cancers. The m...
-
Article
Open AccessExploitation of ATP-sensitive potassium ion (KATP) channels by HPV promotes cervical cancer cell proliferation by contributing to MAPK/AP-1 signalling
Persistent infection with high-risk human papillomaviruses (HPVs) is the causal factor in multiple human malignancies, including >99% of cervical cancers and a growing proportion of oropharyngeal cancers. Prol...
-
Article
Open AccessInhibition of USP14 promotes TNFα-induced cell death in head and neck squamous cell carcinoma (HNSCC)
TNFα is a key mediator of immune, chemotherapy and radiotherapy-induced cytotoxicity, but several cancers, including head and neck squamous cell carcinomas (HNSCC), display resistance to TNFα due to activation...
-
Article
Open AccessE6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer
Human papillomaviruses (HPV) are a major cause of malignancy worldwide, contributing to ~5% of all human cancers including almost all cases of cervical cancer and a growing number of ano-genital and oral cance...
-
Article
Open AccessThe deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer
Protein ubiquitination is a critical regulator of cellular homeostasis. Aberrations in the addition or removal of ubiquitin can result in the development of cancer and key components of the ubiquitination mach...
-
Chapter
Proinflammatory Signaling Pathways and Genomic Signatures in Head and Neck Cancers
The advances in genomics research during the past few decades have significantly improved our biological understanding of head and neck cancers (HNCs), which have resulted in the development of innovations in ...
