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Article
A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cells
Protein interactions guide most cellular processes. Orthogonal hetero-specific protein–protein interaction domains may facilitate better control of engineered biological systems. Here, we report a tunable de n...
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Article
Design of fast proteolysis-based signaling and logic circuits in mammalian cells
Cellular signal transduction is predominantly based on protein interactions and their post-translational modifications, which enable a fast response to input signals. Owing to difficulties in designing new uni...