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Article
Open AccessA Coaching-Based Leadership Program for Women Postdoctoral Fellows at the National Cancer Institute that Cultivates Self-confidence and Persistence in STEMM
Despite making strides in gender equality, women in Science, Technology, Engineering, Mathematics, and Medicine (STEMM) continue to face a persistent underrepresentation in leadership roles. In an effort to re...
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Article
Building Capacity for Global Cancer Research: Existing Opportunities and Future Directions
Cancer incidence and mortality are increasing in low- and middle-income countries (LMICs), where more than 75% of global cancer burden will occur by the year 2040. The primary drivers of cancer morbidity and m...
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Article
Open AccessParacrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo
Macrophages comprise an essential component of the mammary microenvironment necessary for normal gland development. However, there is no viable in vivo model to study their role in normal human breast function. W...
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Article
Open AccessHornerin, an S100 family protein, is functional in breast cells and aberrantly expressed in breast cancer
Recent evidence suggests an emerging role for S100 protein in breast cancer and tumor progression. These ubiquitous proteins are involved in numerous normal and pathological cell functions including inflammato...
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Article
Open AccessCharacterization of ductal and lobular breast carcinomas using novel prolactin receptor isoform specific antibodies
Prolactin is a polypeptide hormone responsible for proliferation and differentiation of the mammary gland. More recently, prolactin's role in mammary carcinogenesis has been studied with greater interest. Stud...
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Article
Open AccessThe normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo
Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unkn...
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Article
16-kDa Prolactin Reduces Angiogenesis, but Not Growth of Human Breast Cancer Tumors In Vivo
Prolactin (PRL) is a peptide hormone necessary for normal growth and development of the human breast. In addition, high levels of PRL in plasma correlate with increased risk of breast cancer, especially among ...
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Article
Open AccessDynamic regulation of CD24 and the invasive, CD44posCD24negphenotype in breast cancer cell lines
The invasive, mesenchymal phenotype of CD44posCD24neg breast cancer cells has made them a promising target for eliminating the metastatic capacity of primary tumors. It has been previously demonstrated that CD44n...
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Article
Msx-1 and Msx-2 in Mammary Gland Development
Homeobox genes do not generally function alone to determine cell fate and morphogenesis. Rather it is the distinct combination of various members of the homeobox family of genes and their spatiotemporal patter...
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Chapter
Whole Organ Culture of the Mouse Mammary Gland
Whole mammary glands from pubescent mice, primed for 9 days with estrogen and progesterone, cultured in the presence of the lactogenic hormone mix of insulin, aldosterone, hydrocortisone, and prolactin develop...
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Chapter
Intramammary Delivery of Hormones, Growth Factors, and Cytokines
Direct delivery of hormones, growth factors, and cytokines to the mammary gland aids in assessing local versus systemically mediated effects. One of the three effective procedures utilizes cholesterol-based pe...
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Article
A comparison of the pulmonary toxicity and chemotherapeutic activity of bleomycin-BAPP to bleomycin and pepleomycin
The pulmonary toxicity and antitumor activity of a new bleomycin analog butylamino-3-propylamino-3-propylamine (Blm-BAPP) was investigated and compared with bleomycin and pepleomycin. Blm-BAPP was significantl...
