Respiratory Medicine
Volume 2 / 2013 to Volume 19 / 2013
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Book Series
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Chapter
Genetics and Genomics of Obesity and Lung Diseases
Both obesity and several respiratory diseases have significant hereditary components. Moreover, in theory, changes in gene regulation and expression caused by obesity could modify the risk of develo** differ...
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Book
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Chapter
Obesity and Asthma: Epidemiology and Clinical Presentation
Children and adults with overweight and obesity are at higher risk of incident asthma. Obesity may also lead to worse asthma morbidity and severity. While the relationship between obesity and asthma is complex...
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Article
Open AccessNasal DNA methylation at three CpG sites predicts childhood allergic disease
Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions that share strong genetic and environmental components. Diagnosis relies on clinical history and measurements of all...
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Article
Open AccessGenome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness
Variability in response to short-acting β2-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants asso...
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Protocol
DNA Methylation and Atopic Diseases
The prevalence of allergic diseases such as asthma is globally increasing, posing threat to the life quality of the affected population. Genome-wide association studies (GWAS) suggest that genetic variations o...
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Article
Open AccessPharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation
A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhoo...
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Article
Open AccessCorrection: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Chapter
Severe Asthma During Adolescence and the Transition to Adulthood
In prior chapters of this book, we have reviewed the epidemiology of severe asthma and have discussed important considerations in the preschool years. Adolescents comprise another important and vulnerable popu...
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Chapter
Future Directions in Severe Childhood Asthma
Prior chapters in this book have covered in detail different aspects of the diagnosis, management, and research in severe pediatric asthma. In this chapter, we will review some of the lessons learned, knowledg...
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Article
Deficiency in AIM2 induces inflammation and adipogenesis in white adipose tissue leading to obesity and insulin resistance
Absent in melanoma 2 (AIM2) is a cytosolic sensor for double-stranded DNA and a tumour suppressor. Binding of double-stranded DNA to AIM2 forms the AIM2 inflammasome, leading to activation of caspase-1 and produc...
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Article
Open AccessThe nasal methylome as a biomarker of asthma and airway inflammation in children
The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylat...
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Article
Measurement Invariance of the Adolescent Quality of Life-Mental Health Scale (AQOL-MHS) across Gender, Age and Treatment Context
The Adolescent Quality of Life-Mental Health Scale (AQOL-MHS) was designed to measure quality of life in clinical samples of Latino adolescents aged 12–18 years, but has also been used in community samples. Th...
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Article
Work-related respiratory symptoms and lung function among solderers in the electronics industry: a meta-analysis
Research on the respiratory effect of exposure to solder fumes in electronics workers has been conducted since the 1970s, but has yielded inconsistent results. The aim of this meta-analysis was to clarify the ...
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Article
Open AccessDiversity of the gut microbiota and eczema in early life
A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results.
