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Article
Open AccessPolarized secretion of Leukemia Inhibitory Factor
The direction of cytokine secretion from polarized cells determines the cytokine's cellular targets. Leukemia inhibitory factor (LIF) belongs to the interleukin-6 (IL-6) family of cytokines and signals through...
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Article
Open AccessPlasma irisin levels predict telomere length in healthy adults
The ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exer...
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Article
Open AccessPlasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels
Irisin is a hormone released mainly from skeletal muscle after exercise which increases adipose tissue energy expenditure. Adipocytes can also release irisin after exercise, acting as a local adipokine to indu...
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Article
Open AccessTrabecular bone organoids: a micron-scale ‘humanised’ prototype designed to study the effects of microgravity and degeneration
Bone is a highly responsive organ, which continuously adapts to the environment it is subjected to in order to withstand metabolic demands. These events are difficult to study in this particular tissue in vivo...
