4,764 Result(s)

Article

Integrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity and immune evasion in lower grade glioma

The expression dysregulation of microRNAs (miRNA) has been widely reported during cancer development, however, the underling mechanism remains largely unanswered. In the present work, we performed a systematic...

Zhen Yang, **aocen Liu, Hao Xu, Andrew E. Teschendorff… in Communications Biology (2024)

Article

Phase separation of RNF214 promotes the progression of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been obse...

Zheng-Jie He, Ke He, Song-Wang Cai, Rui Zhang, Zhong-Bao Shao… in Cell Death & Disease (2024)

Article

Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC

Hepatocellular carcinoma (HCC) is a malignancy that occurs worldwide and is generally associated with poor prognosis. The development of resistance to targeted therapies such as sorafenib is a major challenge ...

Chunli Mo, Weixin You, Yipeng Rao, Zhen** Lin… in Cellular and Molecular Life Sciences (2024)

Article

Functional and evolutionary comparative analysis of the DIR gene family in Nicotiana tabacum L. and Solanum tuberosum L.

The dirigent (DIR) genes encode proteins that act as crucial regulators of plant lignin biosynthesis. In Solanaceae species, members of the DIR gene family are intricately related to plant growth and development,...

Tong Li, Wenbin Luo, Chaofan Du, **aolu Lin, Guojian Lin, Rui Chen… in BMC Genomics (2024)

Article

Metabolomic and transcriptomic analyses of peach leaves and fruits in response to pruning

Pruning is an important cultivation management option that has important effects on peach yield and quality. However, the effects of pruning on the overall genetic and metabolic changes in peach leaves and fru...

**ao-Fei Liu, **u-Hong An, **n-Miao Li, He Zhang, Hong-Bo Cao… in BMC Genomics (2024)

Article

Author Correction: High-yield porphyrin production through metabolic engineering and biocatalysis

Haihong Chen, Yaohong Wang, Weishan Wang, Ting Cao, Lu Zhang… in Nature Biotechnology (2024)

Article

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway

Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), a core circadian gene, plays a crucial role in the develo...

Wenqing Zou, Yiming Lei, Cong Ding, Hongjun **ao, Shunxin Wang… in Cell Death & Disease (2024)

Article

Erratum to: Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival

Jialiang Yang, Yuhong Chen, Tongdan Zou, Bai Xue, Fang Yang… in Science China Life Sciences (2024)

Article

Influenza virus uses mGluR2 as an endocytic receptor to enter cells

Influenza virus infection is initiated by the attachment of the viral haemagglutinin (HA) protein to sialic acid receptors on the host cell surface. Most virus particles enter cells through clathrin-mediated e...

Zixin Ni, **liang Wang, **aofei Yu, Yifan Wang, **gfei Wang… in Nature Microbiology (2024)

Article

Gut fungi of black-necked cranes (Grus nigricollis) respond to dietary changes during wintering

Migratory birds exhibit heterogeneity in foraging strategies during wintering to cope with environmental and migratory pressures, and gut bacteria respond to changes in host diet. However, less is known about ...

Wenhao Li, Lijun Cheng, **n He, Guiwen He, Yutong Liu, Zhenglin Sang… in BMC Microbiology (2024)

Article

A single-cell sequence analysis of mouse subcutaneous white adipose tissue reveals dynamic changes during weaning

Adipose tissue development begins in the fetal period, and continues to expand after birth. Dysregulation of adipose tissue during weaning may predispose individuals to lifelong metabolic disorders. However, t...

Shuwen Qian, Chenyang Zhang, Yan Tang, Mengyuan Dai, Zhihui He… in Communications Biology (2024)

Article

Systematic single-cell analysis reveals dynamic control of transposable element activity orchestrating the endothelial-to-hematopoietic transition

The endothelial-to-hematopoietic transition (EHT) process during definitive hematopoiesis is highly conserved in vertebrates. Stage-specific expression of transposable elements (TEs) has been detected during z...

Cong Feng, Ruxiu Tie, Saige **n, Yuhao Chen, Sida Li, Yifan Chen… in BMC Biology (2024)