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Chapter
Microvascular Structural Alterations and Tissue Perfusion in Hypertension/Diabetes
The development of structural changes in the systemic vasculature is the end result of established hypertension. Indeed, in essential hypertension, small arteries smooth muscle cell are restructured around a s...
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Article
Microvascular Density and Circulating Endothelial Progenitor Cells Before and After Treatment with Incretin Mimetics in Diabetic Patients
Glucagon-like peptide 1-receptor agonists (incretin mimetics) and dipeptidyl peptidase-4 inhibitors (incretin enhancers) have been recently introduced in the treatment of diabetes mellitus. In particular, incr...
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Article
Use of Antihypertensive Drugs in Neoplastic Patients
The introduction of Vascular Endothelial Growth Factor (VEGF) signaling pathway inhibitor treatment has highlighted the role of the baseline activity of the VEFG system for blood pressure regulation. VEGF sign...
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Article
Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice
Some reports have suggested that inflammation in perivascular adipose tissue (PVAT) may be implicated in vascular dysfunction by causing the disappearance of an anticontractile effect. The aim of this study wa...
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Article
Open AccessP2.2 Resistant Hypertension and Structural Alterations of Subcutaneous Small Resistance Arteries
It is was suggested that, in resistant hypertension, the presence of particularly pronounced microvascular alterations may contribute to explain the relative lack of response to treatment. Similarly, in diabet...
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Article
Open AccessP2.1 Aging and Structural Alterations of Subcutaneous Small Resistance Arteries in Hypertensive Patients
It was proposed that early vascular ageing may be an important mechanism of vascular damage in large conductance arteries. However it is not known whether aging may also affect small resistance artery morphology.
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Article
Cerebral small-resistance artery structure and cerebral blood flow in normotensive subjects and hypertensive patients
The aim of this study was to prospectively investigate whether the structure of cerebral small-resistance arteries is related to cerebral perfusion parameters as measured with dynamic susceptibility-weighted c...
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Article
Immune Mechanisms in Hypertension
Low grade inflammation may have a key role in the pathogenesis of hypertension and cardiovascular disease. Several studies showed that both innate and adaptive immune systems may be involved, being T cells the...
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Article
How to Assess Microvascular Structure in Humans
Structural alterations of subcutaneous small resistance arteries, as indicated by an increased media to lumen ratio, are frequently present in hypertensive and/or diabetic patients. However, the evaluation of ...
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Article
Open AccessInterrelationships between macro and microvascular structure and function
Macrovasculature and microvasculature are interrelated, and may influence each other. Microvascular structure is not only the site of vascular resistance but probably also the origin of most of the wave reflec...
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Article
Open AccessIntracellular molecular effects of insulin resistance in patients with metabolic syndrome
Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. Data obtained from muscle biopsies have demonstrated altered insulin signaling (IS) in patients with MetS. The IS regul...
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Article
Functional alterations of mesenteric small resistance arteries in Milan hypertensive and normotensive rats
The Milan hypertensive rat strain (MHS) is a genetic strain in which cardiovascular phenotypes seem to be dependent, at least in part, on adducin gene polymorphisms. The aim of our study was to evaluate the st...
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Article
Coronary Flow Reserve and Small Artery Remodelling in Hypertensive Patients
Objective: To evaluate the relationship between subcutaneous small arteries structure and coronary flow reserve in patients with essential hypertension.
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Article
A strange chest pain after dental surgery
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Article
Remodelling of Small Resistance Arteries in Essential Hypertension
Regardless of the mechanisms that initiate the rise of blood pressure, the development of structural changes in the systemic vasculature is the end result of established hypertension. In essential hypertension...
