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Article
Heritability: What's the point? What is it not for? A human genetics perspective
In this paper, we explain the concept of heritability and describe the different methods and the genotype–phenotype correspondences used to estimate heritability in the specific field of human genetics. Herita...
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Article
Open AccessGenome-wide CNV analysis replicates the association between GSTM1 deletion and bladder cancer: a support for using continuous measurement from SNP-array data
Structural variations such as copy number variants (CNV) influence the expression of different phenotypic traits. Algorithms to identify CNVs through SNP-array platforms are available. The ability to evaluate ...
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Article
Open AccessSelection of SNP subsets for association studies in candidate genes: comparison of the power of different strategies to detect single disease susceptibility locus effects
The recent advances in genoty** and molecular techniques have greatly increased the knowledge of the human genome structure. Millions of polymorphisms are reported and freely available in public databases. A...
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Article
Open AccessImpact of the diagnosis definition on linkage detection
Previous genome scan linkage analyses of the disease Kofendrerd Personality Disorder (KPD) with microsatellites led to detect some regions on chromosomes 1, 3, 5, and 9 that were identical for the three popula...
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Article
Open AccessOn the use of haplotype phylogeny to detect disease susceptibility loci
The cladistic approach proposed by Templeton has been presented as promising for the study of the genetic factors involved in common diseases. This approach allows the joint study of multiple markers within a ...