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Open AccessPLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages
Human genetic studies have linked rare coding variants in microglial genes, such as TREM2, and more recently PLCG2 to Alzheimer’s disease (AD) pathology. The P522R variant in PLCG2 has been shown to confer protec...
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Open AccessTREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapid...
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Article
Open AccessTREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages
TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer’s disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial act...
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Open AccessCorrection: Interventions for treating children and adolescents with overweight and obesity: an overview of Cochrane reviews
This paper was originally published under a standard licence. This has now been amended to a CC BY licence in the PDF and HTML.
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Article
Open AccessInterventions for treating children and adolescents with overweight and obesity: an overview of Cochrane reviews
Children and adolescents with overweight and obesity are a global health concern. This is an integrative overview of six Cochrane systematic reviews, providing an up-to-date synthesis of the evidence examining...
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Article
Open AccessEvaluation of expression and function of the H+/myo-inositol transporter HMIT
The phosphoinositide (PIns) signalling pathway regulates a series of neuronal processes, such as neurotransmitter release, that are thought to be altered in mood disorders. Furthermore, mood-stabilising drugs ...
