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Article
Open AccessCD105+CD90+CD13+ identifies a clonogenic subset of adventitial lung fibroblasts
Mesenchymal cells are important components of specified niches in the lung, and can mediate a wide range of processes including tissue regeneration and repair. Dysregulation of these processes can lead to impr...
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Article
Open AccessQuantifying extracellular matrix turnover in human lung scaffold cultures
Remodelling of the extracellular matrix is accomplished by altering the balance between matrix macromolecule production and degradation. However, it is not well understood how cells balance production of new m...
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Article
Open AccessQuantitative proteomic characterization of lung-MSC and bone marrow-MSC using DIA-mass spectrometry
Mesenchymal stromal cells (MSC) are ideal candidates for cell therapies, due to their immune-regulatory and regenerative properties. We have previously reported that lung-derived MSC are tissue-resident cells ...
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Article
Small heat shock proteins prevent aggregation of citrate synthase and bind to the N-terminal region which is absent in thermostable forms of citrate synthase
Citrate synthase (CS) is often used in chaperone assays since this thermosensitive enzyme aggregates at moderately increased temperatures. Small heat shock proteins (sHsps) are molecular chaperones specialized...
