11 Result(s)

Article

Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients

Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease, with 30% to 40% of patients failing to be cured with available primary therapy. microRNAs (miRNAs) are RNA molecules that attenuate expression of...

Emilia L Lim, Diane L Trinh, David W Scott, Andy Chu, Martin Krzywinski… in Genome Biology (2015)

Article

Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability

Intellectual Disability (ID) is among the most common global disorders, yet etiology is unknown in ~30% of patients despite clinical assessment. Whole genome sequencing (WGS) is able to interrogate the entire ...

Farah R. Zahir, Jill C. Mwenifumbo, Hye-Jung E. Chun, Emilia L. Lim… in BMC Genomics (2017)

Article

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Nat. Med.; 10.1038/nm.4439; corrected online 1 January 2018 In the version of this article initially published online, Figure 1a has two black boxes in the key that are labeled as 'Unknown'; these boxes should...

Hamid Bolouri, Jason E Farrar, Timothy Triche Jr, Rhonda E Ries… in Nature Medicine (2018)

Article

Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

In the version of this article originally published, the color key in Fig. 1a was wrong. In the Cytogenetics key, the box over t(8;21) originally was green. It should have been red, matching the color of the s...

Hamid Bolouri, Jason E Farrar, Timothy Triche Jr, Rhonda E Ries… in Nature Medicine (2019)

Article

Publisher Correction: A clonal expression biomarker associates with lung cancer mortality

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Dhruva Biswas, Nicolai J. Birkbak, Rachel Rosenthal, Crispin T. Hiley… in Nature Medicine (2020)

Article

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some...

Kevin Litchfield, James L. Reading, Emilia L. Lim, Hang Xu, Po Liu… in Nature Communications (2020)

Article

Genomic–transcriptomic evolution in lung cancer and metastasis

Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy¹. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcript...

Carlos Martínez-Ruiz, James R. M. Black, Clare Puttick, Mark S. Hill… in Nature (2023)

Article

The evolution of non-small cell lung cancer metastases in TRACERx

Metastatic disease is responsible for the majority of cancer-related deaths¹. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited pa...

Maise Al Bakir, Ariana Huebner, Carlos Martínez-Ruiz, Kristiana Grigoriadis… in Nature (2023)

Article

The evolution of lung cancer and impact of subclonal selection in TRACERx

Lung cancer is the leading cause of cancer-associated mortality worldwide¹. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer...

Alexander M. Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L. Lim… in Nature (2023)

Article

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)^1,2. Although TLS have been found to correlate with improved...

Kevin W. Ng, Jesse Boumelha, Katey S. S. Enfield, Jorge Almagro, Hongui Cha… in Nature (2023)

Article

Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx

Alexander M. Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L. Lim… in Nature (2024)