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  1. No Access

    Article

    Targeting chromosomal instability in patients with cancer

    Chromosomal instability (CIN) is a hallmark of cancer and a driver of metastatic dissemination, therapeutic resistance, and immune evasion. CIN is present in 60–80% of human cancers and poses a formidable ther...

    Duaa H. Al-Rawi, Emanuele Lettera, Jun Li… in Nature Reviews Clinical Oncology (2024)

  2. Article

    Open Access

    Non-cell-autonomous cancer progression from chromosomal instability

    Chromosomal instability (CIN) is a driver of cancer metastasis1–4, yet the extent to which this effect depends on the immune system remains unknown. Using ContactTracing—a newly developed, validated and benchmark...

    Jun Li, Melissa J. Hubisz, Ethan M. Earlie, Mercedes A. Duran, Christy Hong… in Nature (2023)

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  3. Article

    Open Access

    Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis

    Activating mutations in the BRAF-MAPK pathway have been reported in histiocytoses, hematological inflammatory neoplasms characterized by multi-organ dissemination of pro-inflammatory myeloid cells. Here, we ge...

    Riccardo Biavasco, Emanuele Lettera, Kety Giannetti, Diego Gilioli… in Nature Communications (2021)

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