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Chapter
LMP1 TRAFficking Activates Growth and Survival pathways
Epstein-Barr Virus (EBV) Latent Infection Membrane Protein 1 (LMP1) is expressed in all the EBV related malignancies. LMP1 expression is critical for transformation of human B-cells by EBV. LMP1 expression in ...
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Chapter
Epstein-Barr Virus Recombinants: Use of Positive Selection Markers to Rescue Mutants in EBV Negative B Lymphoma Cells
Epstein-Barr virus (EBV) genetic analyses have been restricted because the in vitro host range is limited to primate B lymphocytes which are largely non-permissive for EBV replication (1). Further, recovery of...
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Chapter
Epstein-Barr Virus Transformation of B Lymphocytes: Molecular Pathogenesis
Primary Epstein-Barr Virus (EBV) infection begins in the oropharynx where the virus establishes persistent infection of epithelial cells through continued cycles of infection, virus replication, cell death, vi...