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Article
Open AccessTrial participants’ self-reported understanding of randomisation phrases in participation information leaflets can be high, but acceptability of some descriptions is low, especially those linked to gambling and luck
Evidence indicates that trial participants often struggle to understand participant information leaflets (PILs) for clinical trials, including the concept of randomisation. We analysed the language used to des...
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Article
Open AccessRegistry-based randomised controlled trials: conduct, advantages and challenges—a systematic review
Registry-based randomised controlled trials (rRCTs) have been described as pragmatic studies utilising patient data embedded in large-scale registries to facilitate key clinical trial procedures including recr...
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Article
Open AccessRetention strategies are routinely communicated to potential trial participants but often differ from what was planned in the trial protocol: an analysis of adult participant information leaflets and their corresponding protocols
Retaining participants in randomised controlled trials (RCTs) is challenging and trial teams are often required to use strategies to ensure retention or improve it. Other than monetary incentives, there is no ...
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Article
Open AccessWhen describing harms and benefits to potential trial participants, participant information leaflets are inadequate
Providing informed consent for trials requires providing trial participants with comprehensive information about the trial, including information about potential risks and benefits. It is required by the ethi...
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Article
Open AccessHow do trial teams plan for retention during the design stage of the trial? A sco** review
Retention to trials is important to ensure the results of the trial are valid and reliable. The SPIRIT guidelines (18b) require “plans to promote participant retention and complete follow-up, including list of...
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Article
Open AccessHow do trial teams plan for retention during the design stage of the trial? A sco** review protocol
Retention remains a major challenge for many clinical trials. The SPIRIT guidelines state the following information on retention should be included in the trial protocol “Plans to promote participant retention...
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Article
Open AccessHow much is the lack of retention evidence costing trial teams in Ireland and the UK?
Evidence to support the use of many retention strategies in clinical trials is lacking. Despite this, trial teams still need to have some form of retention strategy in their trials to try and avoid high attrit...
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Article
Open AccessPatient perceptions of the challenges of recruitment to a renal randomised trial registry: a pilot questionnaire-based study
Randomised controlled trials (RCTs) are the gold standard for demonstrating the efficacy of new therapies. However, issues of external validity often affect result application to real-world settings. Using reg...
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Article
Open AccessManaging clinical trials during COVID-19: experience from a clinical research facility
There is a dearth of literature on best practices for managing clinical trials, and little is understood on the role of the clinical trial manager. The COVID-19 pandemic has brought this into focus, and the co...
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Chapter and Conference Paper
Moulding Contact Lenses
The moulding process in the manufacture of a certain monomer-based product, is modelled using the thin film approximation with the aim of reducing defects in which the mould is partially filled. A simpl...
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Article
Operator- and software-related post-experimental variability and source of error in 2-DE analysis
In the field of proteomics, several approaches have been developed for separating proteins and analyzing their differential relative abundance. One of the oldest, yet still widely used, is 2-DE. Despite the co...
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Article
HIV-1 integrase blocks infection of bacteria by single-stranded DNA and RNA bacteriophages
Expression of human immunodeficiency virus-1 integrase in Escherichia coli, at levels that had no effect on bacterial cell growth, blocked plaque formation by bacteriophages having single-stranded genomic DNA (M1...
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Article
Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3″) (9)
The nucleotide sequence of the spc determinant of the Staphylococcus aureus transposon Tn554 has been determined. This gene encodes a spectinomycin adenyltransferase, AAD(9), that mediates resistance to spectinom...
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Article
Transposition of Tn554 does not generate a target duplication
Transposable elements from prokaryotic and eukaryotic organisms are discrete DNA segments bounded by inverted or directly repeated sequences that insert into non-homologous DNA in a reaction that is independen...
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Article
Physical map** of Staphylococcus aureus penicillinase plasmid pI524: Characterization of an invertible region
The staphylococcal penicillinase plasmid pI524 and a series of derivatives have been extensively mapped by restriction endonuclease digestion and by heteroduplex analysis. We report here the identification of ...
