1 Result(s)

Article

A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance

Despite tremendous progress in precision oncology, adaptive resistance mechanisms limit the long-term effectiveness of molecularly targeted agents. Here we evaluated the pharmacological profile of MTX-531 that...

Christopher E. Whitehead, Elizabeth K. Ziemke… in Nature Cancer (2024)