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Open AccessMutated Toll-like receptor 9 increases Alzheimer’s disease risk by compromising innate immunity protection
The development of Alzheimer’s disease (AD) involves central and peripheral immune deregulation. Gene identification and studies of AD genetic variants of peripheral immune components may aid understanding of ...
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Article
Open AccessRare missense mutations in ABCA7 might increase Alzheimer’s disease risk by plasma membrane exclusion
The adenosine triphosphate–binding cassette subfamily A member 7 gene (ABCA7) is associated with Alzheimer’s disease (AD) in large genome-wide association studies. Targeted sequencing of ABCA7 suggests a role for...