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  1. Article

    Open Access

    Evolution of Th2 responses: characterization of IL-4/13 in sea bass (Dicentrarchus labrax L.) and studies of expression and biological activity

    Th2 immunity is a primary host defence against metazoan pathogens and two of the important cytokines involved in this immune response in mammals are IL-4 and IL-13. Recently the origin and evolution of Th2 imm...

    Valentina Stocchi, Tiehui Wang, Elisa Randelli, Massimo Mazzini… in Scientific Reports (2017)

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  2. Article

    Open Access

    Immunoglobulin T from sea bass (Dicentrarchus labrax L.): molecular characterization, tissue localization and expression after nodavirus infection

    Immunoglobulins (Igs) are fundamental components of the adaptive immune system of vertebrates, with the IgT/IgZ isotype specific of Teleosts. In this paper we describe the identification of an IgT heavy chain ...

    Francesco Buonocore, Valentina Stocchi, Noelia Nunez-Ortiz… in BMC Molecular Biology (2017)

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  3. No Access

    Article

    Majority of TcRβ+ T-lymphocytes located in thymus and midgut of the bony fish, Dicentrarchus labrax (L.)

    Real-time polymerase chain reaction (PCR) and in situ hybridization analyses were performed to investigate the occurrence and distribution of T-lymphocytes expressing TcRβ in intestine and lymphoid tissues of ...

    Nicla Romano, Francesca Rossi, Luigi Abelli, Elisabetta Caccia… in Cell and Tissue Research (2007)

  4. No Access

    Article

    The cytokine IL-1β from the crocodile icefish Chionodraco hamatus (Perciformes: Channichthyidae)

    The immune system of the so-called crocodile icefishes, members of the family Channichthyidae, has been recently investigated to study its morphological and functional organisation, to evidence the presence of...

    Francesco Buonocore, Elisa Randelli, Francesca Paderi, Steve Bird… in Polar Biology (2006)

  5. No Access

    Article

    Biological Activity of Sea Bass (Dicentrarchus labrax L.) Recombinant Interleukin-1β

    Biological activities of a putative mature sea bass interleukin-1β peptide, produced as a recombinant protein (rIL-1β) in Escherichia coli, have been investigated. The rIL-1β contains a 6-...

    Francesco Buonocore, Maria Forlenza, Elisa Randelli… in Marine Biotechnology (2005)

  6. No Access

    Article

    Expression in Escherchia coli and Purification of Sea Bass (Dicentrarchus labrax) Interleukin 1β, a Possible Immunoadjuvant in Aquaculture

    Interleukin 1β (IL-1β) is a pleiotropic cytokine that plays a pivotal role in regulating immune responses. Our group has recently cloned IL-1β from sea bass (Dicentrarchus labrax), one of the main Mediterranean a...

    Francesco Buonocore, Massimo Mazzini, Maria Forlenza… in Marine Biotechnology (2004)