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  1. No Access

    Protocol

    In Silico Clinical Trials: Is It Possible?

    Modeling and simulation (M&S), including in silico (clinical) trials, helps accelerate drug research and development and reduce costs and have coined the term “model-informed drug development (MIDD).” Data-dri...

    Simon Arsène, Yves Parès, Eliott Tixier… in High Performance Computing for Drug Discov… (2024)

  2. Article

    Open Access

    Integration of Heterogeneous Biological Data in Multiscale Mechanistic Model Calibration: Application to Lung Adenocarcinoma

    Mechanistic models are built using knowledge as the primary information source, with well-established biological and physical laws determining the causal relationships within the model. Once the causal structu...

    Jean-Louis Palgen, Angélique Perrillat-Mercerot, Nicoletta Ceres… in Acta Biotheoretica (2022)

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