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Article
Open AccessGlutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
The role of glutaminolysis in providing metabolites to support tumour growth is well-established, but the involvement of glutamine metabolism in invasive processes is yet to be elucidated. Here we show that no...
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Article
Open AccessPhosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
The Rab GTPase effector, Rab-coupling protein (RCP) is known to promote invasive behaviour in vitro by controlling integrin and receptor tyrosine kinase (RTK) trafficking, but how RCP influences metastasis in viv...
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Article
Endosomal integrin signals for survival
The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membra...
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Chapter
Internalisation, Endosomal Trafficking and Recycling of Integrins During Cell Migration and Cancer Invasion
There are now clear indications that endocytosis and recycling of integrins is important during cancer progression, invasion and metastasis. In this chapter, we will review the recent literature outlining the ...