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  1. Article

    Open Access

    Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression

    The transcription factor NF-kappaB is a very interesting target molecule for the design on anti-tumor, anti-inflammatory and pro-apoptotic drugs. However, the application of the widely-used molecular docking c...

    Laura Piccagli, Enrica Fabbri, Monica Borgatti… in BMC Structural Biology (2008)

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  2. Article

    Open Access

    The GCC repeat length in the 5'UTR of MRP1 gene is polymorphic: a functional characterization of its relevance for cystic fibrosis

    Among the members of the ATP binding cassette transporter superfamily, MRPs share the closest homology with the CFTR protein, which is defective in CF disease. MRP1 has been proposed as a potential modifier gene ...

    Elena Nicolis, Matteo Pasetto, Cristina Cigana, Ugo Pradal… in BMC Medical Genetics (2006)

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  3. No Access

    Article

    Analysis of the complete coding region of the CFTR gene in a cohort of CF patients from North-Eastern Italy: identification of 90% of the mutations

    A complete coding-region analysis on 225 cystic fibrosis (CF) chromosomes from a cohort that includes all the affected subjects born in two North-Eastern Italian regions over eight years was performed. In a pr...

    Alberto Bonizzato, Elena Nicolis, Carlo Castellani, Graziella Borgo… in Human Genetics (1995)