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Article
Open AccessA roadmap for ribosome assembly in human mitochondria
Mitochondria contain dedicated ribosomes (mitoribosomes), which synthesize the mitochondrial-encoded core components of the oxidative phosphorylation complexes. The RNA and protein components of mitoribosomes ...
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Article
Open AccessHuman mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control
Translation termination requires release factors that read a STOP codon in the decoding center and subsequently facilitate the hydrolysis of the nascent peptide chain from the peptidyl tRNA within the ribosome...
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Article
Open AccessStructural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
Ribosome biogenesis requires auxiliary factors to promote folding and assembly of ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC) is mediated by conserved GTPases,...
