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  1. No Access

    Article

    Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

    Jeffrey Barrett, Carl Anderson and colleagues report the results of a large genome-wide association study of inflammatory bowel disease. They identify 25 new genome-wide significant loci, 3 of which contain in...

    Katrina M de Lange, Loukas Moutsianas, James C Lee, Christopher A Lamb… in Nature Genetics (2017)

  2. No Access

    Article

    Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

    We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn'...

    Sheila A Fisher, Mark Tremelling, Carl A Anderson, Rhian Gwilliam… in Nature Genetics (2008)

  3. No Access

    Article

    Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

    A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for ...

    Miles Parkes, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling… in Nature Genetics (2007)