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    Article

    Direct Lipido-Metabolomics of Single Floating Cells for Analysis of Circulating Tumor Cells by Live Single-cell Mass Spectrometry

    Direct trap** of a single floating cell, i.e. a white blood cell from a drop of blood, within a nanospray tip was followed by super-sonication after the addition of ionization solvent. Molecular detection of an...

    Eiso Hiyama, Ahmed Ali, Sara Amer, Takanori Harada, Kazumi Shimamoto… in Analytical Sciences (2015)

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    Article

    Pretreatment and one-shot separating analysis of whole catecholamine metabolites in plasma by using LC/MS

    Catecholamines are biogenic amines that play an important role in the nervous system. Some catecholamines have been used as tumor makers of phenochromocytoma, paraganglioma and neuroblastoma. The analysis of t...

    Tomomi Hasegawa, Kastuya Wada, Eiso Hiyama… in Analytical and Bioanalytical Chemistry (2006)

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    Article

    Telomerase detection in the diagnosis and prognosis of cancer

    Telomerase, a critical enzyme responsible ‘for cellular immortality, is usually repressed in somatic cells except for lymphocytes and self-renewal cells, but is activated in approximately 85% of human cancer t...

    Eiso Hiyama, Keiko Hiyama in Cytotechnology (2004)