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Article
Open AccessSingle-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma
Hepatoblastomas (HB) display heterogeneous cellular phenotypes that influence the clinical outcome, but the underlying mechanisms are poorly understood. Here, we use a single-cell multiomic strategy to unravel...
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Article
Usefulness of central radiologic review in clinical trials of children with hepatoblastoma
No previous research papers have reported a comparative survey of local radiologic diagnoses and central review in children with hepatoblastoma.
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Article
Open AccessA new surgical technique for short bowel syndrome
Short bowel syndrome (SBS) is a severe intestinal disease that causes malabsorption. Long-term parental nutrition therapy induces infection and liver failure. For the surgical management of intestinal rehabili...
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Article
Laparoscopic approach for abdominal neuroblastoma in Japan: results from nationwide multicenter survey
Some neuroblastoma (NB) cases are suitable for minimally invasive surgery (MIS), but indication and technical issue are unclear. We assessed the current status of MIS for abdominal NB after mass screening peri...
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Article
Open AccessCancer in adolescents and young adults in Japan: epidemiology and cancer strategy
According to national cancer registry data in Japan, approximately 20,000 adolescents and young adults (AYAs, age 15–39 years) are newly diagnosed with cancer each year. Improvements in treatment and care for ...
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Article
Current thoracoscopic approach for mediastinal neuroblastoma in Japan–results from nationwide multicenter survey
Minimally invasive surgery (MIS) is appropriate for the treatment of some neuroblastomas (NBs); however, the indications and technical issues are unclear. This study aimed to clarify the current status of MIS ...
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Article
An Open-Label Study of the Pharmacokinetics and Tolerability of Once-a-Day Fentanyl Citrate Patch in Japanese Pediatric and Adolescent Patients with Cancer Pain
Transdermal fentanyl is not yet approved for pediatric and adolescent use in Japan.
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Article
Open AccessSingle-cell DNA and RNA sequencing of circulating tumor cells
Single-cell sequencing of circulating tumor cells can precisely represent tumor heterogeneity and provide useful information for cancer treatment and research. After spiking TGW neuroblastoma cells into blood ...
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Article
Open AccessGenetic and epigenetic basis of hepatoblastoma diversity
Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary predisposition and acquired molecular aberrations related to HB clinicopathological diversity are not well understood. Her...
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Article
Open AccessClinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)
To promote precision oncology in clinical practice, the Japanese Society of Medical Oncology, the Japanese Society of Clinical Oncology, and the Japanese Cancer Association, jointly published “Clinical practic...
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Article
TERT promotor region rearrangements analyzed in high-risk neuroblastomas by FISH method and whole genome sequencing
Unfavorable neuroblastomas (NBLs) achieve telomere stabilization via telomerase activation through MYCN amplification, TERT promoter region (TERT-PR) rearrangements, or alternative telomere lengthening of telomer...
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Article
Open AccessJapan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology
The development of novel antitumor agents and accompanying biomarkers has improved survival across several tumor types. Previously, we published provisional clinical opinion for the diagnosis and use of immuno...
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Article
Another point of view on 2017 PRETEXT: reply to Pariente et al.
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Article
2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT)
Imaging is crucial in the assessment of children with a primary hepatic malignancy. Since its inception in 1992, the PRETEXT (PRE-Treatment EXTent of tumor) system has become the primary method of risk stratif...
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Reference Work Entry In depth
Stem Cell Telomeres
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Article
Open AccessPrognostic value of circulating tumour DNA in patients undergoing curative resection for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is frequently diagnosed at an advanced stage, leading to a poor prognosis. Therefore, interest in the development of non-invasive biomarkers for prognostic prediction ha...
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Article
Nerve Growth Factor Expression Is Not Associated with Perineural Invasion in Extrahepatic Cholangiocarcinoma
Although the presence of perineural invasion has been recognized as a poor prognostic factor in extrahepatic cholangiocarcinoma, the molecular mechanisms of perineural invasion in extrahepatic cholangiocarcino...
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Article
Direct Lipido-Metabolomics of Single Floating Cells for Analysis of Circulating Tumor Cells by Live Single-cell Mass Spectrometry
Direct trap** of a single floating cell, i.e. a white blood cell from a drop of blood, within a nanospray tip was followed by super-sonication after the addition of ionization solvent. Molecular detection of an...
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Article
Open AccessThe paediatric hepatic international tumour trial (PHITT): clinical trial design in rare disease
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Living Reference Work Entry In depth
Stem Cell Telomeres
