9 Result(s)
within
Eileen White
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessGlucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer
Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat oxidative stress and support reductive biosynthesis. One major NADPH production route is the oxidative pentose phosphate pat...
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Open AccessLeukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice
Cancer cachexia is a systemic metabolic syndrome characterized by involuntary weight loss, and muscle and adipose tissue wasting. Mechanisms underlying cachexia remain poorly understood. Leukemia inhibitory fa...
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Article
Open AccessSOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, the role of SOD1 in cancer is not fully understood. Herein we describe the generation of an inducible Sod1 knockout i...
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Author Correction: Autophagy maintains tumour growth through circulating arginine
In this Letter, ‘released’ should have been ‘regulated’ in the sentence starting: ‘Deletion of Atg5 in the host similarly regulated circulating arginine and suppressed tumorigenesis...’ This has been corrected on...
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Article
Autophagy maintains tumour growth through circulating arginine
Autophagy captures intracellular components and delivers them to lysosomes, where they are degraded and recycled to sustain metabolism and to enable survival during starvation1–5. Acute, whole-body deletion of th...
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Article
Open AccessParkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson’s disease. Accumulating evidence suggests that Parkin is a tumor suppressor, but the underlying mechanism is poorly understood. He...
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Article
Glucose feeds the TCA cycle via circulating lactate
Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.
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Article
DNA damage enables p73
The'guardian of the genome', p53, is the best-known tumour-suppressor gene. Two other proteins — p63 and p73 — have similar sequences and properties to p53. But p53 is the only one to be induced by DNA damage....
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Article
p53, guardian of Rb
