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    Protocol

    Assessment of Extracellular ATP Concentrations

    Most cells release ATP to the extracellular milieu. Extracellular ATP plays important signaling roles by activating a score of broadly distributed cell surface purinergic receptors (purinoceptors). Biological ...

    Lucia Seminario-Vidal, Eduardo R. Lazarowski, Seiko F. Okada in Bioluminescence (2009)

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    Article

    G-protein-coupled receptors as targets for gene transfer vectors using natural small-molecule ligands

    Gene therapy for cystic fibrosis (CF) has focused on correcting electrolyte transport in airway epithelia. However, success has been limited by the failure of vectors to attach and enter into airway epithelia,...

    Silvia M. Kreda, Raymond J. Pickles, Eduardo R. Lazarowski… in Nature Biotechnology (2000)

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    Chapter

    Pharmacological Selectivities of Molecularly Defined Subtypes of P2Y Receptors

    Burnstock and Kennedy (1985) proposed the first formal subtype expansion past the P2-purinoceptor concept originated by Burnstock (1978). The idea that a subset of P2X and P2Y receptors could account for the p...

    T. Kendall Harden, Robert A. Nicholas, Joel B. Schachter… in The P2 Nucleotide Receptors (1998)