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Article
Open AccessGenetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression
Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment. These risk factors, such as depression and vascular disease, do not affect all...
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Article
Open AccessCHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s disease
Changes in high-affinity nicotinic acetylcholine receptors are intricately connected to neuropathology in Alzheimer’s Disease (AD). Protective and cognitive-enhancing roles for the nicotinic α5 subunit have be...
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Article
Open AccessDiagnostic classification of childhood cancer using multiscale transcriptomics
The causes of pediatric cancers’ distinctiveness compared to adult-onset tumors of the same type are not completely clear and not fully explained by their genomes. In this study, we used an optimized multileve...
