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  1. No Access

    Chapter and Conference Paper

    Missense Mutations at ALA-10 in the Factor IX Propeptide: A Novel Mechanism for Severe Bleeding During Oral Anticoagulant Therapy

    Bleeding complications represent the most common and unwanted side effect of oral anticoagulant therapy. We present a novel mechanism for bleeding during coumarin therapy, attributed to newly described missens...

    J. Oldenburg, E. M. Quenzel, U. Harbrecht… in 27. Hämophilie-Symposion Hamburg 1996 (1998)

  2. No Access

    Article

    Severe bleeding in two patients due to increased sensitivity of factor IX activity to phenprocoumon therapy

     Two male patients with severe and recurrent bleeding episodes under phenprocoumon therapy are reported. Both patients exhibited a strong decrease of their factor IX activities below 1% of normal, whereas the ...

    E.-M. Quenzel, H.-J. Hertfelder, J. Oldenburg in Annals of Hematology (1997)