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Article
α-Satellite DNA methylation in normal individuals and in ICF patients: heterogeneous methylation of constitutive heterochromatin in adult and fetal tissues
The methylation profile of ten α-satellites was investigated in normal individuals and in ICF (Immunodeficiency, Centromeric instability, Facial abnormalities) patients. Two out of three ICF patients showed m...
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Article
Characterization and chromosomal location of two repeated DNAs in three Gerbillus species
Two tandemly repeated DNA sequences of Gerbillus nigeriae (Rodentia) (GN1 and GN2) were isolated and characterized. Both share a 36 bp repeated unit, which includes a 20 bp motif also found in primate alphoid and...
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Article
The prosomal RNA-binding protein p27K is a member of the α-type human prosomal gene family
Monoclonal antibodies demonstrated high conservation during evolution of a prosomal protein of Mr 27 000 and differentiation - specific expression of the epitope. More than 90% of the reacting antigen was foun...
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Article
Detection of 1q polysomy in interphase nuclei of human solid tumors with a biotinylated probe
A biotinylated probe (L23-21) specific for the 1q12 band of human karyotype was used to detect the 1q segment in interphase nuclei of breast and colon carcinomas. This probe was selected because trisomy or pol...
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Article
Acquired chromosome rearrangements in human lymphocytes: effect of aging
A prospective study of structural rearrangements occurring in normal lymphocytes was carried out. For each of two newborns and four young and two old adults, about 1000 metaphases from 72-h and 120 from 48-h c...
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Article
Karyotypie diversity and taxonomic problems in the genus Arvicanthis (Rodentia, Muridae)
The analyses of R- and C-banding patterns of chromosomes of Arvicanthis niloticus originating from two different localities (Egypt and Central African Republic) revealed karyotypic differences caused by one peric...
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Article
The rate of chromosome breakage is age dependent in lymphocytes of adult controls
Chromosome breaks and chromatid-type lesions from a prospective study of more than 1000 lymphocyte karyotypes from each of six controls were analysed. These lesions were more frequent in older (75 years old on...
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Article
Non random position of metaphasic chromosomes: A study of radiation induced and constitutional chromosome rearrangements
The rearranged chromosomes derived from reciprocal translocations or dicentric-acentric formations, observed 48 h after their induction by irradiation at Go phase, have a clear tendency to be closer together t...
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Article
Complete or almost complete analogy of chromosome banding between the baboon (Papio papio) and man
The karyotype of the baboon (Papio papio) was studied using several staining techniques: Q bands, R bands, T bands, C bands, G 11.6 bands, and after incorporation of BrdU. When compared with the karyotypes of the...
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Article
Localization of chromatid breaks in Fanconi's anemia, using three consecutive stains
The location of 339 break points was analyzed in three patients with Fanconi's anemia, using three consecutive stains: ordinary Giemsa, Q-banding, and R-banding. Almost all the breaks seem to take place in the...