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Non random position of metaphasic chromosomes: A study of radiation induced and constitutional chromosome rearrangements

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Summary

The rearranged chromosomes derived from reciprocal translocations or dicentric-acentric formations, observed 48 h after their induction by irradiation at Go phase, have a clear tendency to be closer together than their normal homologues. This tendency disappears in longer cultures, and does not exist when many different constitutional reciprocal translocations are considered together. It indicates that the chromosomes having exchanged segments remain adjacent at the following metaphase, and thus, that metaphase plates reflect, at least partially, the interphase arrangement of chromosomes.

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Authors and Affiliations

  1. Institut de Progenèse, 15, rue de l'Ecole de Médecine, F-75270, Paris Cedex 06, France

    B. Dutrillaux, E. Viegas-Péquignot, A. Aurias, M. Mouthuy & M. Prieur

  2. Institut de Sureté Nucléaire Département de Protection, Services de Pathologie et de Protection Sanitaire, Commissariat à l'Energie Atomique, B.P. no 6, F-92260, Fontenay-Aux-Roses, France

    B. Dutrillaux

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  1. B. Dutrillaux
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  2. E. Viegas-Péquignot
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  3. A. Aurias
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  4. M. Mouthuy
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  5. M. Prieur
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Dutrillaux, B., Viegas-Péquignot, E., Aurias, A. et al. Non random position of metaphasic chromosomes: A study of radiation induced and constitutional chromosome rearrangements. Hum Genet 59, 208–210 (1981). https://doi.org/10.1007/BF00283665

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  • DOI: https://doi.org/10.1007/BF00283665

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