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Article
1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline exerts a neuroprotective effect and normalises redox homeostasis in a rat model of cerebral ischemia/reperfusion
Ischemia is one of the main etiological factors of stroke and is associated with the development of energy deficiency, oxidative stress, and inflammation. An abrupt restoration of blood flow, called reperfusio...
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Article
Correction to: Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson’s Disease
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Article
Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson’s Disease
A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidan...
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Article
Activity of Antioxidant Defense Enzymes in Rats with Experimental Allergic Encephalomyelitis
We studied activities of antioxidant system enzymes in tissues of rats with experimental allergic encephalomyelitis. It was shown that the development of pathology is accompanied by deformation of the neurons ...
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Article
The Effect of 6-Hydroxy-2,2,4-Trimethyl-1,2-Dihydroquinoline on the Intensity of Free Radical Processes and Activity of Oxidative Metabolism Enzymes in Rats with Toxic Liver Injury
The effect of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline on markers of hepatocyte cytolysis (aspartate transaminase, alanine transaminase and gamma-glutamyl transpeptidase), parameters reflecting the state...
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Article
The effect of biguanide derivatives on antioxidant status during the development of oxidative stress
The intensity of free radical processes, activity of antioxidant enzymes (superoxide dismutase, catalase), and the content of low molecular weight antioxidants (reduced glutathione, citrate) in skeletal muscle...
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Article
Synthesis and Estimation of the Influence of 2,4-Dimethoxyphenylbiguanide on the Glutathione Antioxidant System Activity in Heart and Blood Serum of Rats with Experimental Rheumatoid Arthritis
A synthetic method for 2,4-dimethoxyphenylbiguanide, which was selected using the Prediction of Activity Spectra of Substances (PASS) computer program, was developed. The influence of this novel biguanidine de...
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Article
Effects of Thioctic Acid on the Oxidative Status Tissues in Rheumatoid Arthritis in Rats
Biochemiluminescence, aconitate hydratase activity, and citrate contents were studied in rat serum and muscle in normal animals and in experimental rheumatoid arthritis; the actions of thioctic acid on the bac...
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Article
Activity of Glutathione Antioxidant System and NADPH-Generating Enzymes in Rats with Experimental Rheumatoid Arthritis
Induction of rheumatoid arthritis in rats was accompanied by an increase in diene conjugate content and glutathione reductase and glutathione peroxidase activities in muscles and blood serum. These changes can...
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Article
Influence of 2,4-dimethoxyphenylbiguanide on antioxidant status in rat heart and blood serum during myocardial infarction
Administration of 2,4-dimethoxyphenylbiguanide to rats with experimental myocardial infarction decreased the activity of cardiomyocyte-cytolysis marker enzymes in rat blood serum and the extent of free-radical...
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Article
Synthesis and effect of biguanide derivatives on biochemiluminescence and level of reduced glutathione in rat blood serum and brain under ischemia-reperfusion conditions
We have studied the effect of the newly synthesized biguanides N-[amino(imino)methyl]morpholine-4-carboximidamide (I) and N-[amino(imino)methyl]piperidine-1-carboximidamide (II) on biochemiluminescence (BCL) para...
