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Potato Ring Rot in Norway: Occurrence and Control
Potato ring rot, caused by the bacterium Clavibacter michiganensis subspecies sepedonicus, is considered to be one of the internationally most important seed potato diseases (Smith et al.; Eur J Plant Pathol 107:...
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Article
The proteins of the Hepatitis C virus: Their features and interactions with intracellular protein phosphorylation
Chronic infection with Hepatitis C virus (HCV) often results in cirrhosis and enhances the probability of develo** hepatocellular carcinoma (HCC). The underlying mechanisms that lead to malignant transformatio...
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Session 22 other topics
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Session 17 Ecophysiology
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Investigation of the inhibition pathway of glucosamine synthase by N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid by semiempirical quantum mechanical and molecular mechanics methods
Glucosamine synthase (E.C. 2.6.1.16) is a promising target in antifungal drug design. It has been reported that its potent inhibitor, N3-(4-methoxyfu-maroyl)-L-2,3-diaminopropanoic acid (FMDP), inactivates the en...
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A theoretical study of glucosamine synthase
Continuing our theoretical studies of glucosamine synthase catalysis, we have carried out MNDO and ab initio calculations of the first stage of the reaction, which involves the attack of a cysteine thiol group...
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Influence of net charge on the aggregation and solubility behaviour of amphotericin B and its derivatives in aqueous media
The poor solubility of polyene antibiotics in aqueous media limits their application in the therapy of systemic fungal infections. In the present paper we have demonstrated that the ionic state (net electrical...
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Comparative conformational analysis of cholesterol and ergosterol by molecular mechanics
A comparative conformational analysis of cholesterol and ergosterol has been carried out using molecular mechanics methods. These studies are aimed at giving a better understanding of the molecular nature of t...
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Growth inhibitory effect of antibiotic tetaine on yeast and mycelial forms of Candida albicans
The mycelial (M) form of Candida albicans is more sensitive to the action of the antibiotic tetaine than the yeast (Y) form. Tetaine, at low concentrations about 1 μg/ml also inhibits Y-M transition. It causes se...
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Presynaptic receptor systems on the noradrenergic neurones of rat brain
Occurrence and properties of receptors modulating release of noradrenaline were studied in slices of rat occipital cortex and, less extensively, of rat hypothalamus and cerebellar cortex. The slices were prein...
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Crystal and molecular structure of anhydroerythromycinA cyclic carbonateN-methyl iodide
The crystal and molecular structure of C39H66INO13 · CH3OH has been determined by single-crystal x-ray diffraction analysis. The compound crystallizes in the monoclinic space, groupP21, witha =14.35(1),b=14.38(1)...
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The antibiotic edeine IX: The isolation and the composition of edeine D
Edein D wurde aus dem komplexen Antibioticum Edein mit Hilfe von Verteilungs-Chromatographie abgetrennt. Als Bausteine von Edein D wurden 3-Amino-3-phenyl-propionsäure, 3-Amino-2-hydroxypropionsäure, 2,3-Diami...
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Potassiumless Death of Saccharomyces cerevisiae Cells treated with N-Succinyl Perimycin and the Reversal of Fungicidal Action of the Antibiotic by Potassium Ions
N-SUCCINYL PERIMYCIN1 is a synthetic derivative of heptaene macrolide antifungal antibiotic2. The advantage of this substance is that, unlike the original polyenes, it forms readily water soluble salts, for examp...