16 Result(s)

Article

Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma

The SMOOTHENED inhibitor vismodegib is FDA approved for advanced basal cell carcinoma (BCC), and shows promise in clinical trials for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma (MB) patients. Clinical exper...

J Rodriguez-Blanco, L Pednekar, C Penas, B Li, V Martin, J Long, E Lee… in Oncogene (2017)

Article

Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias

High expression of the ETS family transcription factor ERG is associated with poor clinical outcome in acute myeloid leukemia (AML) and acute T-cell lymphoblastic leukemia (T-ALL). In murine models, high ERG e...

M L Tursky, D Beck, J A I Thoms, Y Huang, A Kumari, A Unnikrishnan, K Knezevic… in Leukemia (2015)

Article

Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy

Met is a receptor tyrosine kinase that promotes cancer progression. In addition, Met has been implicated in resistance of tumors to various targeted therapies such as epidermal growth factor receptor inhibitor...

B Kim, S Wang, J M Lee, Y Jeong, T Ahn, D-S Son, H W Park, H-s Yoo, Y-J Song… in Oncogene (2015)

Article

A role for oleoylethanolamide in chronic lymphocytic leukemia

Oleoylethanolamide (OEA) is a bioactive lipid that stimulates nuclear and G protein-coupled receptors and regulates appetite and fat metabolism. It has not previously been shown to have a role in cancer. Howev...

M Masoodi, E Lee, M Eiden, A Bahlo, Y Shi, R B Ceddia, C Baccei, P Prasit… in Leukemia (2014)

Article

Estimating risks for variants of unknown significance according to their predicted pathogenicity classes with application to BRCA1

Sequence-based testing of disease-susceptibility genes has identified many variants of unknown significance (VUSs) whose pathogenicity is unknown at the time of their measurement. Female breast cancer cases ag...

J. G. Dowty, E. Lee, R. McKean-Cowdin… in Breast Cancer Research and Treatment (2014)

Article

PPAR-alpha is a therapeutic target for chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) cells with aggressive clinical properties express lipoprotein lipase (LPL), which generates activating ligands for the nuclear receptor peroxisome proliferator activated rece...

D E Spaner, E Lee, Y Shi, F Wen, Y Li, S Tung, L McCaw, K Wong, H Gary-Gouy… in Leukemia (2013)

Article

Identification of a pivotal endocytosis motif in c-Met and selective modulation of HGF-dependent aggressiveness of cancer using the 16-mer endocytic peptide

Since c-Met has an important role in the development of cancer, it is considered as an attractive target for cancer therapy. Although molecular mechanisms for oncogenic property of c-Met have been actively inv...

K-W Cho, J H Park, C-W Park, D Lee, E Lee, D J Kim, K J Kim, S H Yoon, Y Park… in Oncogene (2013)

Article

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells

Multidrug resistance (MDR), a significant impediment to the successful treatment of cancer clinically, has been attributed to the overexpression of P-glycoprotein (P-gp), a plasma membrane multidrug efflux tra...

M Bebawy, V Combes, E Lee, R Jaiswal, J Gong, A Bonhoure, G E R Grau in Leukemia (2009)

Article

Defective TGF-β signaling sensitizes human cancer cells to rapamycin

mTOR, the mammalian target of rapamycin, is a critical target of survival signals in many human cancers. In the absence of serum, rapamycin induces apoptosis in MDA-MB-231 human breast cancer cells. However, i...

N Gadir, D N Jackson, E Lee, D A Foster in Oncogene (2008)

Chapter and Conference Paper

Homozygous Deletion of the p16 Gene in Childhood Acute Lymphoblastic Leukemia

pl6/MTSl (multiple tumor suppressor)/CDK4I (cyclin-dependent kinase 4 inhibitor) is a putative tumor suppressor gene involved in carcinogenesis in a wide variety of tissues. To study the involvement of the pl6...

T. Seriu, S. Takeuchi, C. W. Miller, A. Tobler, J. W. G. Janssen… in Acute Leukemias VI (1997)

Article

American Society of Colon and Rectal Surgeons 95th Annual Convention Podium and Poster Abstracts June 9–14, 1996 Seattle, Washington

D. Obrand, P. H. Gordon, S. Rowley, R. H. Grace, S. Rai… in Diseases of the Colon & Rectum (1996)

Article

Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients

According to the field cancerisation theory the entire upper aerodigestive tract has been mutagenised, thereby placing the affected individual at risk for the development of one or more cancers. To investigate...

AL Smith, J Hung, L Walker, TE Rogers, F Vuitch, E Lee… in British Journal of Cancer (1996)

Chapter and Conference Paper

The In Vitro Analysis of Biochemical Changes Relevant to Skin Carcinogenesis

The phenotypic alterations produced in mouse skin cells during the multistage development of squamous cancer have been well documented. In normal skin, all proliferating cells are confined to the basal cell co...

S. H. Yuspa, K. Punnonen, E. Lee… in Skin Carcinogenesis in Man and in Experime… (1993)

Article

American Society of Colon and Rectal Surgeons 91st Annual Convention Podium and Poster abstracts

P. Lechner, P. Lind, G. Binter, R. W. Golub, B. A. Kerner… in Diseases of the Colon & Rectum (1992)

Article

Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88)

J. C. Barrett, C. A. Afshari, L. A. Annab… in Journal of Cancer Research and Clinical On… (1991)