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    Article

    Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer

    Increased glucose consumption is a hallmark of cancer cells. The increased consumption and subsequent metabolism of glucose during proliferation creates the need for a constant supply of NAD, a co-factor in gl...

    E A Hanse, C Ruan, M Kachman, D Wang, X H Lowman, A Kelekar in Oncogene (2017)

  2. Article

    Transcription factor C/EBP-β induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17–92 cluster in differentiating AML cells

    PHLPP2, a member of the PH-domain leucine-rich repeat protein phosphatase (PHLPP) family, which targets oncogenic kinases, has been actively investigated as a tumor suppressor in solid tumors. Little is known,...

    Y Yan, E A Hanse, K Stedman, J M Benson, X H Lowman… in Cell Death & Differentiation (2016)

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