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Article
Real-world cost- effectiveness analysis: Tumor Treating Fields for newly diagnosed glioblastoma in China
Glioblastoma (GBM) stands as the most aggressive and prevalent primary brain malignancy. Tumor Treating Fields (TTFields), an innovative therapy complementing chemotherapy for GBM treatment, which can signific...
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Article
Cost-Effectiveness Analysis of Sintilimab Plus Chemotherapy in Advanced Non-Squamous Non-Small Cell Lung Cancer: A Societal Perspective
The updated ORIENT-11 study demonstrated that sintilimab, when combined with chemotherapy, had promising survival advantage compared to standard chemotherapy alone in the first-line treatment for previously un...
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Article
Open AccessDiffDomain enables identification of structurally reorganized topologically associating domains
Topologically associating domains (TADs) are critical structural units in three-dimensional genome organization of mammalian genome. Dynamic reorganizations of TADs between health and disease states are associ...
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Article
Open AccessCircular RNA CCT3 is a unique molecular marker in bladder cancer
This study surveyed circular RNA CCT3 in bladder cancer (BCa). We recruited 85 BCa patients and 40 normal controls (Normal) and collected clinical specimens for analysis. circRNA CCT3 expression was analyzed b...
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Article
The function of steroid terminal monooxygenase in cholesterol or phytosterol degradation by the Mycobacterium neoaurum NRRL B-3805
Cholesterol and phytosterols can be served as the substrates for Actinobacteria to produce the precursors used in the synthesis of steroidal medicines. Cytochrome P450s from CYP125 and CYP142 families initiates t...
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Article
Open Accesshsa_circ_0003596, as a novel oncogene, regulates the malignant behavior of renal cell carcinoma by modulating glycolysis
This research was planned to analyze hsa_circ_0003596 (circCOL5A1) and glycolysis-focused mechanisms in renal cell carcinoma (RCC).
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Article
Comparative Analysis of Nutritional Composition Between GM and Non-GM Soybeans and Soybean Oils by NMR and GC-FID Techniques
The differences in nutrition and health benefit between genetically modified (GM) and non-genetically modified (NG) foods have been attracting many concerns from the public and scientific fields. The combinati...
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Article
Correction to: Cost-Effectiveness of Linaclotide Compared to Osmotic Laxatives in the Treatment of Irritable Bowel Syndrome with Constipation in China
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Article
Cost-Effectiveness of Linaclotide Compared to Osmotic Laxatives in the Treatment of Irritable Bowel Syndrome with Constipation in China
Linaclotide, a selective agonist of guanylate cyclase C, was highly recommended for the treatment of irritable bowel syndrome with constipation (IBS-C). However, the cost-effectiveness of linaclotide in Chines...
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Chapter and Conference Paper
DiffDomain Enables Identification of Structurally Reorganized Topologically Associating Domains
The recent development of map** technologies, such as Hi-C, that probes the 3D genome organization reveals that a chromosome is divided into topologically associating domains (TADs). TADs are genomic regions...
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Article
Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase
Reductive desymmetrization of 2,2-disubstituted prochiral 1,3-cyclodiketones to 2,2-disubstituted-3-hydroxycycloketones is a highly desired transformation for the construction of complex molecules with multipl...
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Chapter and Conference Paper
A Novel Semi-supervised Adaboost Technique Based on Improved Tri-training
With the development of the network, network attacks become more frequent and serious, so network security is becoming more and more important
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Article
Numerical simulation of cold-lap defects during casting filling process
Cold lap is one of the common defects in casting productions, which could result in poor surface accuracy and mechanical properties of castings. The cold-lap formation process is difficult to observe directly ...
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Article
Prediction of gas entrapment defects during zinc alloy high-pressure die casting based on gas-liquid multiphase flow model
Zinc alloy is the preferred material for high-pressure die-casting (HPDC) production because of its good casting and mechanical properties, and the most common problem in zinc alloy die casting is gas entrapme...
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Article
Open AccessFind_tfSBP: find thermodynamics-feasible and smallest balanced pathways with high yield from large-scale metabolic networks
Biologically meaningful metabolic pathways are important references in the design of industrial bacterium. At present, constraint-based method is the only way to model and simulate a genome-scale metabolic net...
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Article
Characterization of new recombinant 3-ketosteroid-Δ1-dehydrogenases for the biotransformation of steroids
3-Ketosteroid-Δ1-dehydrogenases (KstDs [EC 1.3.99.4]) catalyze the Δ1-dehydrogenation of steroids and are a class of important enzymes for steroid biotransformations. In this study, we cloned 12 putative KstD-enc...
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Article
Semi-rational engineering of cytochrome CYP153A from Marinobacter aquaeolei for improved ω-hydroxylation activity towards oleic acid
ω-Hydroxy oleic acid is an important intermediate for the synthesis of certain polyesters and polyamides. In this study, a functional CYP153A/putidaredoxin (Pdx)/putidaredoxin reductase (Pdr) hybrid system was...
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Article
Heat Transfer Model of Directional Solidification by LMC Process for Superalloy Casting Based on Finite Element Method
With the rapid development of the aviation industry, the turbine blade, a critical component of the aeronautical engine, has come to be widely produced by liquid-metal cooling (LMC) process. A temperature- and...
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Article
Open AccessNew recombinant cyclohexylamine oxidase variants for deracemization of secondary amines by orthogonally assaying designed mutants with structurally diverse substrates
To further expand the substrate range of the cyclohexylamine oxidase (CHAO) from Brevibacterium oxydans, a library of diverse mutants was created and assayed toward a group of structurally diverse substrates. Amo...
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Chapter
Specialty Enzymes for Chemical Needs
Chemical processes are vital for the manufacturing of goods that meet the human’s growing needs; on the other hand, they have resulted in increasing air pollution and environmental contamination. It is desirab...
