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Article
Open AccessDistinct effects of blood pressure parameters on Alzheimer’s and vascular markers in 1,952 Asian individuals without dementia
Risk factors for cardiovascular disease, including elevated blood pressure, are known to increase risk of Alzheimer’s disease. There has been increasing awareness of the relationship between long-term blood pr...
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Article
Open AccessEffects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea
Early-onset dementia (EOD, onset age < 65) and late-onset dementia (LOD, onset age ≥ 65) exhibit distinct features. Understanding the risk factors for dementia development and mortality in EOD and LOD respecti...
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Article
Open AccessEffects of workbook training using editorials and newspaper articles in adults with preclinical stage of dementia
Early detection and intervention in individuals in the pre-clinical stage of dementia are crucial. This study aimed to examine whether there are significant differences in (1) word retrieval, (2) subjective co...
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Article
Open AccessEnhancing foveal avascular zone analysis for Alzheimer’s diagnosis with AI segmentation and machine learning using multiple radiomic features
We propose a hybrid technique that employs artificial intelligence (AI)-based segmentation and machine learning classification using multiple features extracted from the foveal avascular zone (FAZ)—a retinal b...
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Article
Open AccessDistinct effects of cholesterol profile components on amyloid and vascular burdens
Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels with Aβ and cerebral small vessel disease (CSVD) burdens are not full...
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Article
Open AccessIdentification of potential biomarkers related to mesenchymal stem cell response in patients with Alzheimer’s disease
Preclinical studies showed that mesenchymal stem cells (MSCs) ameliorate tau phosphorylation, amyloid-beta accumulation, and inflammation in Alzheimer’s disease (AD) mouse models via secretion of neurotrophic ...
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Article
Open AccessDifferent effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity
A growing body of evidence shows differences in the prevalence of cardiometabolic syndrome (CMS) and dementia based on gender and ethnicity. However, there is a paucity of information about ethnic- and gender-...
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Article
Open AccessThe effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic
We investigated the relevance of various imaging markers for the clinical trajectory of cerebral amyloid angiopathy (CAA) patients in a memory clinic.
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Article
Open AccessDevelopment and clinical validation of CT-based regional modified Centiloid method for amyloid PET
The standard Centiloid (CL) method was proposed to harmonize and quantify global 18F-labeled amyloid beta (Aβ) PET ligands using MRI as an anatomical reference. However, there is need for harmonizing and quantify...
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Article
Open AccessGender-specific relationship between thigh muscle and fat mass and brain amyloid-β positivity
The relationship of specific body composition in the thighs and brain amyloid-beta (Aβ) deposition remained unclear, although there were growing evidence that higher muscle and fat mass in thighs had a protect...
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Article
Open AccessMachine learning-based automatic estimation of cortical atrophy using brain computed tomography images
Cortical atrophy is measured clinically according to established visual rating scales based on magnetic resonance imaging (MRI). Although brain MRI is the primary imaging marker for neurodegeneration, computed...
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Article
Open AccessDecreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study
Decreased visual acuity (VA) is reported to be a risk factor for dementia. However, the association between VA and cortical thickness has not been established. We investigated the association between VA and co...
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Article
Open AccessPerformance of the plasma Aβ42/Aβ40 ratio, measured with a novel HPLC-MS/MS method, as a biomarker of amyloid PET status in a DPUK-KOREAN cohort
We assessed the feasibility of plasma Aβ42/Aβ40 determined using a novel liquid chromatography-mass spectrometry method (LC-MS) as a useful biomarker of PET status in a Korean cohort from the DPUK Study.
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Article
Open AccessIntracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial
Alzheimer’s disease is the most common cause of dementia, and currently, there is no disease-modifying treatment. Favorable functional outcomes and reduction of amyloid levels were observed following transplan...
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Article
Open AccessEffect of education on functional network edge efficiency in Alzheimer’s disease
We investigated the effect of education on the edge efficiency in resting state functional networks (RSFNs) in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease dementia (ADD). We collected the...
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Article
Open AccessIdentifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population
Genome-wide association studies (GWAS) have identified a number of genetic variants for Alzheimer’s disease (AD). However, most GWAS were conducted in individuals of European ancestry, and non-European populat...
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Article
Open AccessDifferential effects of risk factors on the cognitive trajectory of early- and late-onset Alzheimer’s disease
Although few studies have shown that risk factors for Alzheimer’s disease (AD) are associated with cognitive decline in AD, not much is known whether the impact of risk factors differs between early-onset AD (...
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Article
Open AccessNovel Alzheimer’s disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers
Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with a complex genetic etiology. Besides the apolipoprotein E ε4 (APOE ε4) allele, a few dozen other genetic loci associated with AD ...
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Article
Open AccessPredicting amyloid positivity in patients with mild cognitive impairment using a radiomics approach
Predicting amyloid positivity in patients with mild cognitive impairment (MCI) is crucial. In the present study, we predicted amyloid positivity with structural MRI using a radiomics approach. From MR images (...
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Article
Open AccessPrediction of tau accumulation in prodromal Alzheimer’s disease using an ensemble machine learning approach
We developed machine learning (ML) algorithms to predict abnormal tau accumulation among patients with prodromal AD. We recruited 64 patients with prodromal AD using the Alzheimer’s Disease Neuroimaging Initia...
