22 Result(s)
within
Duk L Na
Medicine & Public Health
-
Article
Harmonisation of PET imaging features with different amyloid ligands using machine learning-based classifier
In this study, we used machine learning to develop a new method derived from a ligand-independent amyloid (Aβ) positron emission tomography (PET) classifier to harmonise different Aβ ligands.
-
Article
Open AccessNovel Alzheimer’s disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers
Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with a complex genetic etiology. Besides the apolipoprotein E ε4 (APOE ε4) allele, a few dozen other genetic loci associated with AD ...
-
Article
Correction to: Staging and quantification of florbetaben PET images using machine learning: impact of predicted regional cortical tracer uptake and amyloid stage on clinical outcomes
Incorrect acknowledgments.
-
Article
Open AccessStaging and quantification of florbetaben PET images using machine learning: impact of predicted regional cortical tracer uptake and amyloid stage on clinical outcomes
We developed a machine learning–based classifier for in vivo amyloid positron emission tomography (PET) staging, quantified cortical uptake of the PET tracer by using a machine learning method, and investigate...
-
Article
A new Centiloid method for 18F-florbetaben and 18F-flutemetamol PET without conversion to PiB
We developed a new method to directly calculate Centiloid (CL) units of 18F-florbetaben (FBB) and 18F-flutemetamol (FMM) without conversion to the PiB standardized uptake value ratio (SUVR).
-
Article
Correction to: A new Centiloid method for 18F-florbetaben and 18F-flutemetamol PET without conversion to PiB
Funding information from the original version of this article was incomplete. Complete information is presented here.
-
Article
Correction to: Staging and quantification of florbetaben PET images using machine learning: impact of predicted regional cortical tracer uptake and amyloid stage on clinical outcomes
The Table 2 in the original version of this article contained a mistake in the alignment. Correct Table 2 presentation is presented here.
-
Article
Open AccessThe Dementias Platform UK (DPUK) Data Portal
The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, ful...
-
Article
Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients
To apply an AT (Aβ/tau) classification system to subcortical vascular cognitive impairment (SVCI) patients following recently developed biomarker-based criteria of Alzheimer’s disease (AD), and to investigate ...
-
Article
Open AccessPrediction of cognitive impairment via deep learning trained with multi-center neuropsychological test data
Neuropsychological tests (NPTs) are important tools for informing diagnoses of cognitive impairment (CI). However, interpreting NPTs requires specialists and is thus time-consuming. To streamline the applicati...
-
Article
Open AccessTHK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report
THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine o...
-
Article
Clinical significance of amyloid β positivity in patients with probable cerebral amyloid angiopathy markers
We investigated the frequency and clinical significance of amyloid β (Aβ) positivity on PET in patients with cerebral amyloid angiopathy (CAA).
-
Article
Amyloid involvement in subcortical regions predicts cognitive decline
We estimated whether amyloid involvement in subcortical regions may predict cognitive impairment, and established an amyloid staging scheme based on degree of subcortical amyloid involvement.
-
Article
Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia
Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer’s disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers su...
-
Article
Prognostic value of amyloid PET scan in normal pressure hydrocephalus
Amyloid positron emission tomography ([18F] florbetaben (FBB) PET) can be used to determine concomitant Alzheimer’s disease (AD) in idiopathic normal pressure hydrocephalus (iNPH) patients. FBB PET scans and t...
-
Article
The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment
Subcortical vascular cognitive impairment (SVCI) refers to cognitive impairment associated with small vessel disease. Motor intentional disorders (MID) have been reported in patients with SVCI. However, there ...
-
Article
Open AccessInference of brain pathway activities for Alzheimer's disease classification
Alzheimer's disease (AD) is a neurodegenerative and progressive disorder that results in brain malfunctions. Resting-state (RS) functional magnetic resonance imaging (fMRI) techniques have been successfully ap...
-
Article
Vestibular hemispatial neglect: patterns and possible mechanism
Recent reports have suggested that hemispatial neglect may be a vestibular disorder at the cortical level, based on the similarities of symptoms and neural correlates between the two phenomena. If this is the ...
-
Article
Correlation between instrumental activities of daily living and white matter hyperintensities in amnestic mild cognitive impairment: results of a cross-sectional study
Although some studies have supported the association between white matter hyperintensities (WMH) and cognitive impairment, whether WMH are associated with the impairments in instrumental activities of daily li...
-
Article
Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) study
The objective of this study was to investigate the relationship between neurologic signs and cognitive dysfunction in subcortical ischemic vascular dementia (SIVD). 121 patients with SIVD were recruited from m...
