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  1. No Access

    Article

    Nucleotide sequence analysis of precore and proximal core regions in patients with chronic hepatitis B treated with interferon

    The aim of the study was to estimate the prevalence of HBeAg defective mutants among patients with chronic hepatitis B (CHB) in the United States and to study the effect of interferon-α (IFN-α) on determining ...

    Tomasz Laskus MD, PhD, Dr. Jorge Rakela MD… in Digestive Diseases and Sciences (1995)

  2. No Access

    Article

    Nucleotide sequence analysis of the precore region in patients with spontaneous reactivation of chronic hepatitis B

    The role of HBV precore mutations in the spontaneous reactivation of chronic hepatitis B (CHB) is currently unknown. We studied 10 patients with CHB; five were HBeAg+ (group I) and five were anti-HBe+ (group II)....

    Tomasz Laskus MD, PhD, Dr. Jorge Rakela MD… in Digestive Diseases and Sciences (1994)

  3. No Access

    Article

    Lack of evidence for hepatitis B virus (HBV) infection in fulminant non-A, non-B hepatitis

    We studied eight patients who had orthotopic liver transplantation for fulminant hepatic failure in the course of acute non-A, non-B hepatitis. HBV DNA was searched for extensively in the liver tissue by PCR u...

    Tomasz Laskus MD, PhD, Dr. Jorge Rakela MD… in Digestive Diseases and Sciences (1994)

  4. No Access

    Article

    Randomized controlled trial of recombinant alpha-2a-interferon for chronic hepatitis C

    We enrolled 32 patients with chronic hepatitis C into a randomized, controlled trial to evaluate the efficacy of recombinant alpha-2a-interferon treatment. Sixteen patients were randomized to receive 1.5 milli...

    David D. Douglas MD, Dr. Jorge Rakela MD… in Digestive Diseases and Sciences (1993)

  5. No Access

    Article

    A double-blinded, randomized trial of hydrocortisone in acute hepatic failure

    The Acute Hepatic Failure Study Group (AHFSG) has conducted a double-blinded, randomized evaluation of hydrocortisone in patients with acute hepatic failure. From July 1975 through August 1978, a 38-month peri...

    Dr. Jorge Rakela MD, James W. Mosley MD… in Digestive Diseases and Sciences (1991)

  6. No Access

    Article

    Late manifestation of chronic liver disease in adults with alpha-1-antitrypsin deficiency

    A review of 19 adult patients with alpha-1-antitrypsin deficiency (A1AT deficiency) and chronic liver disease revealed a late onset of symptomatic hepatic abnormalities in this condition. Thirteen patients (68%) ...

    Dr. Jorge Rakela MD, Markus Goldschmiedt MD… in Digestive Diseases and Sciences (1987)

  7. No Access

    Article

    Diagnostic laparoscopy in gastroenterology

    Between 1970 and 1983, we performed 1121 diagnostic laparoscopies in 1119 patients. More than 50% of the examinations were performed for malignant disease. An adequate examination was accomplished in 917 (82%)...

    Piet C. De Groen MD, Dr. Jorge Rakela MD… in Digestive Diseases and Sciences (1987)

  8. No Access

    Article

    Acute type a hepatitis in three patients with chronic HBV infection

    We have studied three patients with chronic HBV infection who had a superimposed bout of type A hepatitis. The patients recovered uneventfully without observing a change in their clinical course afterwards. In...

    Chris Conteas MD, Henry Kao MD, Dr. Jorge Rakela MD… in Digestive Diseases and Sciences (1983)