132 Result(s)

Article

The m⁶A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism

N⁶-adenosine methylation (m⁶A) is critical for controlling cancer cell growth and tumorigenesis. However, the function and detailed mechanism of how m⁶A methyltransferases modulate m⁶A levels on specific targets ...

Su Hwan Park, **-Sung Ju, Hyunmin Woo, Hye ** Yun… in Experimental & Molecular Medicine (2024)

Article

Glutamine-derived aspartate is required for eIF5A hypusination-mediated translation of HIF-1α to induce the polarization of tumor-associated macrophages

Tumor-associated macrophages (TAMs) are vital contributors to the growth, metastasis, and therapeutic resistance of various cancers, including hepatocellular carcinoma (HCC). However, the exact phenotype of TA...

Dong-Ho Kim, Yoo Na Kang, Jonghwa **, Mihyang Park… in Experimental & Molecular Medicine (2024)

Article

Association between irritable bowel syndrome and Parkinson’s disease by Cohort study and Mendelian randomization analysis

This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson’s disease (PD) utilizing prospective cohort study and Mendelian randomization. The dataset contained a subst...

Zhi-yun Wang, Dong-rui Ma, Meng-jie Li, Yuan-yuan Liang… in npj Parkinson's Disease (2024)

Article

The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress

Mitophagy induction upon mitochondrial stress is critical for maintaining mitochondrial homeostasis and cellular function. Here, we found that Mst1/2 (Stk3/4), key regulators of the Hippo pathway, are required...

Dae ** Jeong, Jee-Hyun Um, Young Yeon Kim… in Experimental & Molecular Medicine (2024)

Article

Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy

Protein arginine methyltransferases (PRMTs) modulate diverse cellular processes, including stress responses. The present study explored the role of Prmt7 in protecting against menopause-associated cardiomyopat...

Byeong-Yun Ahn, Yan Zhang, Shibo Wei, Yideul Jeong… in Experimental & Molecular Medicine (2024)

Article

Association between circulating ECM-associated molecules and cardiovascular outcomes in hemodialysis patients: a multicenter prospective cohort study

Hemodialysis patients are susceptible to cardiovascular remodeling, which increases the risk of cardiovascular morbidity and mortality. Circulating extracellular matrix (ECM)-associated molecules increase duri...

Hyeon Seok Hwang, Jihyun Baek, So-Young Lee, Hye Yun Jeong… in Biomarker Research (2024)

Article

Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer

Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various in...

Ji Eun Yu, In Jun Yeo, Sang-Bae Han, Jaesuk Yun… in Experimental & Molecular Medicine (2024)

Article

The mechanism of ferroptosis and its related diseases

Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative s...

Shijian Feng, Dan Tang, Yichang Wang, **ang Li, Hui Bao… in Molecular Biomedicine (2023)

Article

Identification of exosomal microRNA panel as diagnostic and prognostic biomarker for small cell lung cancer

Small cell lung cancer (SCLC) has an exceptionally poor prognosis; as most of the cases are initially diagnosed as extensive disease with hematogenous metastasis. Therefore, the early diagnosis of SCLC is very...

Dong Ha Kim, Hyojeong Park, Yun Jung Choi, Kyungtaek Im, Chae Won Lee… in Biomarker Research (2023)

Article

MicroRNA 29a therapy for CEACAM6-expressing lung adenocarcinoma

Non-coding microRNAs (miRNAs) play critical roles in tumor progression and hold great promise as therapeutic agents for multiple cancers. MicroRNA 29a (miR-29a) is a tumor suppressor miRNA that inhibits cancer...

Seung-Myoung Son, Jieun Yun, Dong-Wook Kim, Young-Suk Jung, Sang-Bae Han… in BMC Cancer (2023)

Article

Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke

Stroke usually causes prolonged or lifelong disability, owing to the permanent loss of infarcted tissue. Although a variety of stem cell transplantation has been explored to improve neuronal defect behavior by...

Shi-Ying Cao, Di Yang, Zhen-Quan Huang, Yu-Hui Lin, Hai-Yin Wu… in npj Regenerative Medicine (2023)

Article

Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation

The serum glycoprotein leucine-rich ɑ-2-glycoprotein 1 (LRG1), primarily produced by hepatocytes and neutrophils, is a multifunctional protein that modulates various signaling cascades, mainly TGFβ signaling. ...

Jimin Yang, Guo Nan Yin, Do-Kyun Kim, Ah-reum Han… in Experimental & Molecular Medicine (2023)

Article

Identification of hub genes and pathways in lung metastatic colorectal cancer

Colorectal cancer (CRC) is one of the most prevalent types of malignant tumours. Metastasis is the leading cause of cancer-related mortality, with lung metastases accounting for 32.9% of all metastatic CRCs. H...

Wei Dai, Caiyao Guo, Yu Wang, Yumei Li, Renjian **e, Junhong Wu, Baole Yao… in BMC Cancer (2023)

Article

Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law… in Nature Genetics (2023)