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Article
Increases in serotonergic neuronal activity following intracerebroventricular administration of AF64A in rats
Changes in the serotonergic nervous system after the intracerebroventricular (i.c.v.) administration of ethylcholine aziridinium (AF64A, 3 nmol/each ventricle) were studied in rats. Two weeks after the infusio...
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Article
Effects of Dehydroevodiamine Exposure on Glutamate Release and Uptake in the Cultured Cerebellar Cells
Dehydroevodiamine has been reported to have neuroprotective and antiamnesic effects. This study examined the effects of dehydroevodiamine on glutamate release and uptake in cultured cerebellar cells. Chronic d...
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Article
Chronic exposure of nicotine modulates the expressions of the cerebellar glial glutamate transporters in Rats
Rats were given nicotine (25 ppm) in their drinking water at the start of their mating period in order to study the expressions of glutamate transporter subtypes in cerebellar astrocytes following the chronic ...
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Article
Changes in the Glutamate Release and Uptake of Cerebellar Cells in Perinatally Nicotine-Exposed Rat Pups
Cerebellar granule and glial cells were cultured from 7 day-old rat pups after pre- and post-natal nicotine treatment. Ten days later, the basal release of glutamate in the granule cells prepared from the pre-...
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Article
Impairments of learning and memory following intracerebroventricular administration of AF64A in rats
Three types of learning and memory tests (Morris water maze, active and passive avoidance) were performed in rats following intracerebroventricular infusion of ethylcholine aziridium (AF64A). In Morris water m...
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Article
Effects of chronic lead exposure on glutamate release and uptake in cerebellar cells of rat pups
Changes in the release and uptake of glutamate in cerebellar granule and glial cells of offspring of lead-exposed mothers were determined. In cultured cerebellar granule cells exposed to lead for 5 days, gluta...
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Article
Effects of I.C.V. administration of ethylcholine aziridinium (AF64A) on the central glutamatergic nervous systems in rats
Changes in glutamatergic nervous activities following intracerebroventricular (icv) administration of ethylcholine aziridinium (AF64A) were studied in rats. The levels of total glutamate, those of glutamate in...
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Article
Effects of intracerebroventricular administration of ethylcholine aziridinium (AF64A) on dopaminergic nervous systems
Changes in dopaminergic activities were investigaed after the intracerebroventricular (icv) administration of ethylcholine aziridium (AF64A) in rats. The levels of dopamine (DA) and metabolites, the activities...
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Article
Effects of ethylcholine aziridinium, scopolamine and morphine on learning behaviors in morris water maze
To assess the learning behaviors of the various chemicals, such as ethylcholine aziridinium (AF64A), scopolamine and morphine, the chemicals were administered into either rat or mice. And water maze tests were...
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Article
Anin vivo study of dopamine metabolism in hyperglycemic rat striatum
The changes in the levels of the extracellular dopamine metabolites and the responses to various dopamine agents were studied by using microdialysis in hyperglycemic rat striatum. The hyperglycemia were induce...
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Article
Changes in the distribution of dopamine and it's metabolites in streptozotocin-induced diabetic rat striatum
Changes in the distribution of dopamine and its metabolites, activities of monoamine oxidase, and dopamine uptake were studied in hyperglycemic rat striatum. The hyperglycemia was induced by the administration...
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Article
Testicular degeneration and sperm loss induced by chronic administration of cocaine in mice
The effect of cocaine on reproductive system were studied in male ICR mice. Daily injection of cocaine HCl (10, and 40 mg/kg, s.c. for 15 days) disrupted epididymal sperm levels and testicular morphology. Thes...
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Article
Effects of bicuculline on [3H]SR 95531 binding in discrete regions of rat brains
Effects of bicuculline in vitro, and acute and chronic treatment of a subconvulsive dose of bicuculline on [3H]SR 95531 binding to discrete regions of rat brains were studied in Sprague-Dawley rats. Scatchard ana...
