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Article
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit
The authors use transgenic mice to show that zinc modulates NMDA receptors containing the NR2A subunit, and that this interaction influences pain control in vivo.
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Article
Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses
The role of the opioid system in controlling pain1, reward and addiction2,3 is well established, but its role in regulating other emotional responses is poorly documented in pharmacology4. The μ-, δ- and κ- opioi...