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  1. No Access

    Article

    Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

    The synthesis of poly(ADP-ribose) (PAR) reconfigures the local chromatin environment and recruits DNA-repair complexes to damaged chromatin. PAR degradation by poly(ADP-ribose) glycohydrolase (PARG) is essenti...

    Song My Hoang, Nicole Kaminski, Ragini Bhargava… in Nature Structural & Molecular Biology (2020)

  2. Article

    Open Access

    Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells

    There is mounting evidence of androgen receptor signaling inducing genome instability and changing DNA repair capacity in prostate cancer cells. Expression of genes associated with base excision repair (BER) i...

    Manqi Zhang, Yanhao Lai, Judy L. Vasquez, Dominic I. James… in Scientific Reports (2020)

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  3. No Access

    Protocol

    Studying Catabolism of Protein ADP-Ribosylation

    Protein ADP-ribosylation is a conserved posttranslational modification that regulates many major cellular functions, such as DNA repair, transcription, translation, signal transduction, stress response, cell d...

    Luca Palazzo, Dominic I. James, Ian D. Waddell, Ivan Ahel in Poly(ADP-Ribose) Polymerase (2017)