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Large-scale association analyses identify host factors influencing human gut microbiome composition

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  1. Article

    Open Access

    The gut microbiota and depressive symptoms across ethnic groups

    The gut microbiome is thought to play a role in depressive disorders, which makes it an attractive target for interventions. Both the microbiome and depressive symptom levels vary substantially across ethnic g...

    Jos A. Bosch, Max Nieuwdorp, Aeilko H. Zwinderman in Nature Communications (2022)

  2. Article

    Open Access

    Gut microbiome-wide association study of depressive symptoms

    Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a n...

    Djawad Radjabzadeh, Jos A. Bosch, André G. Uitterlinden in Nature Communications (2022)

  3. Article

    Open Access

    Diversity, compositional and functional differences between gut microbiota of children and adults

    The gut microbiota has been shown to play diverse roles in human health and disease although the underlying mechanisms have not yet been fully elucidated. Large cohort studies can provide further understanding...

    Djawad Radjabzadeh, Cindy G. Boer, Sanne A. Beth, Pelle van der Wal in Scientific Reports (2020)

  4. Article

    Open Access

    Relationship between gut microbiota and circulating metabolites in population-based cohorts

    Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metab...

    Dina Vo**ovic, Djawad Radjabzadeh, Alexander Kurilshikov in Nature Communications (2019)

  5. Article

    Open Access

    Intestinal microbiome composition and its relation to joint pain and inflammation

    Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. ...

    Cindy G. Boer, Djawad Radjabzadeh, Carolina Medina-Gomez in Nature Communications (2019)

  6. Article

    Open Access

    Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative

    In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human metabolism, immunology, and diseases. Many studies are investigating the forces un...

    Jun Wang, Alexander Kurilshikov, Djawad Radjabzadeh, Williams Turpin in Microbiome (2018)