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Article
Open AccessThe gut microbiota and depressive symptoms across ethnic groups
The gut microbiome is thought to play a role in depressive disorders, which makes it an attractive target for interventions. Both the microbiome and depressive symptom levels vary substantially across ethnic g...
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Article
Open AccessGut microbiome-wide association study of depressive symptoms
Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a n...
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Article
Large-scale association analyses identify host factors influencing human gut microbiome composition
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microb...
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Article
Open AccessDiversity, compositional and functional differences between gut microbiota of children and adults
The gut microbiota has been shown to play diverse roles in human health and disease although the underlying mechanisms have not yet been fully elucidated. Large cohort studies can provide further understanding...
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Article
Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas
Progress in high-throughput metabolic profiling provides unprecedented opportunities to obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular Research Infrastructure of the...
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Article
Open AccessRelationship between gut microbiota and circulating metabolites in population-based cohorts
Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metab...
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Article
Open AccessIntestinal microbiome composition and its relation to joint pain and inflammation
Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. ...
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Article
Open AccessMeta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative
In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human metabolism, immunology, and diseases. Many studies are investigating the forces un...
