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  1. Article

    Open Access

    RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway

    Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors of the head and neck. Vasculogenic mimicry (VM) is crucial for tumor growth and metastasis and refers to the formation of flu...

    Qingwen Zhu, **nyu Zhang, Fei Lu, Siyu Miao… in Cell Communication and Signaling (2024)

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  2. Article

    Open Access

    Norepinephrine protects against cochlear outer hair cell damage and noise-induced hearing loss via α2A-adrenergic receptor

    The cochlear sympathetic system plays a key role in auditory function and susceptibility to noise-induced hearing loss (NIHL). The formation of reactive oxygen species (ROS) is a well-documented process in NIH...

    Chaoyong Tian, Yang Yang, Renfeng Wang, Yao Li, Fei Sun, Jun Chen… in BMC Neuroscience (2024)

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  3. Article

    Open Access

    Lysophosphatidic acid exerts protective effects on HEI-OC1 cells against cytotoxicity of cisplatin by decreasing apoptosis, excessive autophagy, and accumulation of ROS

    Lysophosphatidic acid (LPA) is an active phospholipid signaling molecule that binds to six specific G protein-coupled receptors (LPA1-6) on the cell surface and exerts a variety of biological functions, including...

    **aogang An, Cui** Zhong, Bang Han, Erfang Chen, Qingwen Zhu… in Cell Death Discovery (2023)

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  4. No Access

    Article

    Cuproptosis-related LINC02454 as a biomarker for laryngeal squamous cell carcinoma based on a novel risk model and in vitro and in vivo analyses

    Laryngeal squamous cell carcinomas (LSCCs) are aggressive tumors with the second-highest morbidity rate in patients with head and neck squamous cell carcinoma. Cuproptosis is a type of programmed cell death th...

    Qingwen Zhu, Ruyue Zhang, Fei Lu… in Journal of Cancer Research and Clinical On… (2023)

  5. Article

    Open Access

    A novel splice site variant c.1183 + 1 G > C in DFNA5 causing autosomal dominant nonsyndromic hearing loss in a Chinese family

    The most frequent clinical presentation of autosomal dominant nonsyndromic hearing loss (ADNSHL) is bilateral, symmetrical, postlingual progressive sensorineural hearing loss, which begins with impairment at h...

    Qiong Li, Shujuan Wang, Pengfei Liang, Wei Li, Jian Wang, Bei Fan… in BMC Medical Genomics (2022)

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  6. No Access

    Article

    Upregulation of HSP60 expression in the postnatal rat cochlea and rats with drug-induced hearing loss

    Heat shock protein 60 (HSP60) is a highly conserved chaperone molecule that plays important roles in mediating some physiological and pathological functions. However, researchers have not yet determined whethe...

    Keyong Tian, Yongli Song, Ke Zhou, Bo Yue, Yang Qiu, Fei Sun… in Cell Stress and Chaperones (2018)

  7. No Access

    Article

    A differentially amplified motion in the ear for near-threshold sound detection

    The mammalian cochlea can detect near-threshold sound signals by mechanically amplifying sub-nanometer vibrations of the basilar membrane. This study describes vibration enhancement in the hearing organ opposi...

    Fangyi Chen, Dingjun Zha, Anders Fridberger, Jiefu Zheng… in Nature Neuroscience (2011)