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Article
Conservation and change of the developmentally crucial fushi tarazu gene in Drosophila
We have studied the evolutionary changes occurring in the noncoding regions around the developmentally important fushi tarazu (ftz) gene in a total of 11 species in the genus Drosophila. Previous molecular develo...
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Article
Structure and regulation of the fushi tarazu gene from Drosophila hydei
The Drosophila melanogaster segmentation gene fushi tarazu (ftz) encodes a homeodomain-type transcription factor involved in the control of larval pattern formation. Loss of function mutations cause an embryonic ...
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Article
Determination of the relaxation time spectrum from dynamic moduli using an edge preserving regularization method
For the numerical determination of a continuous relaxation time spectrum from rheological data so-called regularization methods are necessary. The regularization method based on Tikhonov regularization and co...
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Article
Green fluorescent protein as a convenient and versatile marker for studies on functional genomics in Drosophila
Gene function can be deduced from lack or gain of activity. For the manipulation of gene doses or activity in Drosophila, a set of P-based vectors was constructed containing green fluorescent protein as marker. ...
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Article
Open AccessThe Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee
In Drosophila melanogaster the Enhancer of split-Complex [E(spl)-C] consists of seven highly related genes encoding basic helix-loop-helix (bHLH) repressors and intermingled, four genes that belong to the Bearded...
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Article
Open AccessProtein Kinase D regulates several aspects of development in Drosophila melanogaster
Protein Kinase D (PKD) is an effector of diacylglycerol-regulated signaling pathways. Three isoforms are known in mammals that have been linked to diverse cellular functions including regulation of cell prolif...
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Article
Open AccessThe tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signaling in Drosophila melanogaster
The Notch signaling pathway is fundamental to the regulation of many cell fate decisions in eumetazoans. Not surprisingly, members of this pathway are highly conserved even between vertebrates and invertebrate...
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Article
Open AccessKnowledge management for systems biology a general and visually driven framework applied to translational medicine
To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow predictive hypothe...
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Article
Open AccessData integration in the era of omics: current and future challenges
To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through lar...
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Article
Wissensmanagement für Systembiologie und -medizin
The evolution of bioinformatics from tool development to building knowledge management solutions is a game changer across the life sciences. Systems biology is the foundation. The convergence of experimental a...
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Article
Open AccessSimulation environment and graphical visualization environment: a COPD use-case
Today, many different tools are developed to execute and visualize physiological models that represent the human physiology. Most of these tools run models written in very specific programming languages which ...
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Article
Open AccessBiomedical research in a Digital Health Framework
This article describes a Digital Health Framework (DHF), benefitting from the lessons learnt during the three-year life span of the FP7 Synergy-COPD project. The DHF aims to embrace the emerging requirements -...
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Article
Open AccessSystems Medicine: from molecular features and models to the clinic in COPD
Chronic Obstructive Pulmonary Disease (COPD) patients are characterized by heterogeneous clinical manifestations and patterns of disease progression. Two major factors that can be used to identify COPD subtypes a...
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Article
Open AccessThe COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research
Previously we generated a chronic obstructive pulmonary disease (COPD) specific knowledge base (http://www.copdknowledgebase.eu) from clinical and experiment...
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Article
Open AccessWorkforce preparation: the Biohealth computing model for Master and PhD students
The article addresses the strategic role of workforce preparation in the process of adoption of Systems Medicine as a driver of biomedical research in the new health paradigm. It reports on relevant initiative...
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Article
Open AccessChronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management
Heterogeneity in clinical manifestations and disease progression in Chronic Obstructive Pulmonary Disease (COPD) lead to consequences for patient health risk assessment, stratification and management. Implicit...
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Article
Open AccessImplementing systems medicine within healthcare
The cause of a complex disease cannot be pinpointed to a single origin; rather, a highly complex network of many factors that interact on different levels over time and space is disturbed. This complexity requ...
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Article
Evaluation of the hazard potentials of river suspended particulate matter and floodplain soils in the Rhine basin using chemical analysis and in vitro bioassays
The purpose of the present study was to assess the hazard potentials of contaminated suspended particulate matter (SPM) sampled during a flood event for floodplain soils using in vitro bioassays and chemical a...
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Article
Open AccessChainRank, a chain prioritisation method for contextualisation of biological networks
Advances in high throughput technologies and growth of biomedical knowledge have contributed to an exponential increase in associative data. These data can be represented in the form of complex networks of bio...
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Article
Open AccessIn vivo analysis of internal ribosome entry at the Hairless locus by genome engineering in Drosophila
Cell communication in metazoans requires the highly conserved Notch signaling pathway, which is subjected to strict regulation of both activation and silencing. In Drosophila melanogaster, silencing involves the ...
