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Open AccessAuthor Correction: Pulmonary vascular reactivity in growth restricted fetuses using computational modelling and machine learning analysis of fetal Doppler waveforms
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Open AccessPulmonary vascular reactivity in growth restricted fetuses using computational modelling and machine learning analysis of fetal Doppler waveforms
The aim of this study was to investigate the pulmonary vasculature in baseline conditions and after maternal hyperoxygenation in growth restricted fetuses (FGR). A prospective cohort study of singleton pregnan...
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Open AccessGOLD COPD DOCUMENT 2023: a brief update for practicing cardiologists
Many patients seen by cardiologists suffer chronic obstructive pulmonary disease (COPD) in addition to their primary cardiovascular problem. Yet, quite often COPD has not been diagnosed and, consequently, pati...
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Open AccessIron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through the...
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Open AccessLung immune signatures define two groups of end-stage IPF patients
The role of the immune system in the pathobiology of Idiopathic Pulmonary Fibrosis (IPF) is controversial.
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Open AccessGold 2023: Highlights for primary care
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Open AccessElevated plasma levels of epithelial and endothelial cell markers in COVID-19 survivors with reduced lung diffusing capacity six months after hospital discharge
Some COVID-19 survivors present lung function abnormalities during follow-up, particularly reduced carbon monoxide lung diffusing capacity (DLCO). To investigate risk factors and underlying pathophysiology, we...
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Open AccessLow birth weight as a potential risk factor for severe COVID-19 in adults
The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease...
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Open AccessHeme metabolism genes Downregulated in COPD Cachexia
Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify d...
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Open AccessReduced airway levels of fatty-acid binding protein 4 in COPD: relationship with airway infection and disease severity
For still unclear reasons, chronic airway infection often occurs in patients with Chronic Obstructive Pulmonary Disease (COPD), particularly in those with more severe airflow limitation. Fatty-acid binding pro...
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Open AccessMulti-level immune response network in mild-moderate Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is associated with an abnormal pulmonary and systemic immune response to tobacco smoking. Yet, how do immune cells relate within and between these two biological co...
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Open AccessRelationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients
The respiratory microbiome is altered in COPD patients but its relationship with core components of the disease, such as the severity of airflow limitation, the frequency of exacerbations or the circulating le...
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Open AccessIt’s more than low BMI: prevalence of cachexia and associated mortality in COPD
Cachexia is associated with increased mortality risk among chronic obstructive pulmonary disease (COPD) patients. However, low body mass index (BMI) as opposed to cachexia is often used, particularly when calc...
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Open AccessDo sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis
Previous studies have identified lung, sputum or blood transcriptomic biomarkers associated with the severity of airflow limitation in COPD. Yet, it is not clear whether the lung pathobiology is mirrored by th...
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Open AccessThe Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD
Genome-wide mRNA profiling in lung tissue from human and animal models can provide novel insights into the pathogenesis of chronic obstructive pulmonary disease (COPD). While 6 months of smoke exposure are wid...
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Open AccessCharacterization, localization and comparison of c-Kit+ lung cells in never smokers and smokers with and without COPD
c-Kit + lung stem cells have been described in the human healthy lung. Their potential relation with smoking and/or chronic obstructive pulmonary disease (COPD) is unknown.
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Open AccessBone marrow characterization in COPD: a multi-level network analysis
Bone marrow (BM) produces hematopoietic and progenitor cells that contribute to distant organ inflammation and repair. Chronic obstructive pulmonary disease (COPD) is characterized by defective lung repair. Ye...
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Open AccessCorrection to: Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both
In the original publication [1] is an error in table 1. The correct version can be found in this Erratum:
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Open AccessComparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both
Exposure to noxious gases and particles contained in both tobacco smoking (TS) and biomass smoke (BS) are well recognized environmental risk factors for chronic obstructive pulmonary disease (COPD). COPD is ch...
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Open AccessHaemophilus influenzae induces steroid-resistant inflammatory responses in COPD
Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder partially resistant to glucocorticoids. A reduced histone deacetylase (HDAC) activity has been proposed to explain this resistance. Haemoph...
